Why does TOF cause anemia?
Background Relative iron deficiency is common among Tetralogy of Fallot (TF) patients and is resulted by inadequate iron supplies for erythropoiesis. The compensatory mechanism is ineffective because the high-elevated hematocrit levels is not accompanied by an increase in oxygen binding capacity.
Can congenital heart cause anemia?
CHD patients frequently have low oxygen saturation in their blood because of inappropriate intra-cardiac communication. The need for an increased circulating haemoglobin mass in cyanotic infants puts a severe stress on their endogenous and dietary iron supplies resulting in relative iron deficiency anaemia.
What are the physiological consequences of transposition of the great vessels?
Although this operation is lifesaving, problems may occur later in life, including: Narrowing of the arteries that supply blood to the heart (coronary arteries) Heart rhythm abnormalities (arrhythmias) Heart muscle weakness or stiffness leading to heart failure.
How does congenital heart disease increase hemoglobin?
Decreased arterial oxygen saturation in cyanotic congenital heart disease causes a compensatory rise in haemoglobin and haematocrit levels. There is an inverse correlation between arterial oxygen saturation and haemoglobin/haematocrit. This holds true as long as the erythropoiesis is not restricted by other factors.
What is the meaning of TOF?
Tetralogy of Fallot (TOF) in Children. Tetralogy of Fallot (TOF) is a cardiac anomaly that refers to a combination of four related heart defects that commonly occur together. The four defects are: Ventricular septal defect (VSD) − a hole between the right and left pumping chambers of the heart.
Can CAD cause anemia?
Introduction. The mechanisms and pathophysiology of anemia in cardiovascular and coronary artery disease (CAD) are complex and multifactorial. Acute anemia can produce immediate hemodynamic changes related to changes in blood viscosity, arterial dilatation, vascular resistance, and stroke volume.
What is Levo transposition of the great arteries?
Levo-Transposition of the great arteries is an acyanotic congenital heart defect in which the primary arteries (the aorta and the pulmonary artery) are transposed, with the aorta anterior and to the left of the pulmonary artery; the morphological left and right ventricles with their corresponding atrioventricular …
Can VSD cause anemia?
In addition, sporadic reports linking anaemia to PNA or PH amongst patients with acyanotic ventricular septal defect (VSD) have been publish. VSD is the second commonest CHD after bicuspid aortic valve4,9, and solitary cases account for almost 20%.
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