Why pioglitazone has been banned?
Government of India had suspended the manufacture, sale and distribution of pioglitazone on June 18, 2013 citing concerns of risk of urinary bladder cancer and other heart related problems as adverse effects of the drug.
What is pioglitazone used for?
Pioglitazone is a medicine used to treat type 2 diabetes. Type 2 diabetes is an illness where the body doesn’t make enough insulin, or the insulin that it makes doesn’t work properly. This can cause high blood sugar levels (hyperglycaemia).
Why is pioglitazone bad for you?
Actos (pioglitazone) can cause fluid to build up in your body. This can cause heart failure if it’s not caught in time. The risk is greater with a higher dose. Tell your provider about any unexpected or sudden weight gain, swelling in your arms or legs, or trouble breathing.
What are the benefits of pioglitazone?
Pioglitazone is known to improve insulin sensitivity, glycemic control, dyslipidemia, hypertension, and microalbuminuria in patients with T2DM. Pioglitazone decreases fasting and postprandial plasma glucose levels by improving the sensitivity of hepatic and peripheral (muscle) tissue to insulin.
What is the side effects of pioglitazone?
More common
- Blurred vision or other changes in vision.
- flushed, dry skin.
- fruit-like breath odor.
- headache.
- increased thirst.
- increased urination.
- muscle pain or soreness.
- problems with your teeth.
Is pioglitazone still banned in India?
As expected, the Indian government has revoked its suspension of the type 2 diabetes drug pioglitazone. However, it has stipulated that the agent should not be used as first-line treatment for diabetes and that it should carry a boxed warning relating to bladder cancer.
What is the side effect of pioglitazone?
Common side effects may include: headache; muscle pain; or. cold symptoms such as stuffy nose, sinus pain, sneezing, sore throat.
Is pioglitazone bad for kidneys?
The pharmacokinetic properties of pioglitazone are ideally suited for patients with renal insufficiency. Although there are possible side effects (mainly fluid retention and weight gain and–very rarely–hepatotoxicity). Pioglitazone has a good safety profile in diabetic patients with impaired renal function.
When should you stop taking pioglitazone?
Pioglitazone can cause or worsen congestive heart failure. You should not use this medicine if you have severe or uncontrolled heart failure. Stop using this medicine and call your doctor at once if you have shortness of breath (especially when lying down), unusual tiredness, swelling, or rapid weight gain.
Does pioglitazone cause weight gain?
Although pioglitazone causes a significant decrease in FBS, HbA1C and triglyceride levels, it is associated with weight gain, which would limit its utility.
Is pioglitazone banned in USA?
Pioglitazone increases the risk of bladder cancer, heart failure and eye problems. As of now, US FDA has issued a warning and not banned Pioglitazone but Germany and France have banned it.
What are the symptoms of pioglitazone?