What is the structure of benzimidazole?
C7H6N2
Benzimidazole/Formula
What is the use of benzimidazole*?
Abstract:Benzimidazole and its derivatives are regarded as an important heterocyclic motif that exhibits a wide range of pharmaceutical applications including anticancers, antihypertensives, antivirals, antifungals, anti-HIVs, anti-convulsants, and anti-diabetics.
What is the pharmacological significance of benzimidazole ring?
The benzimidazole moiety is useful for the development of novel medicinal compounds in pharmaceutical field. Benzimidazole is also a vital pharmacophore, a privileged sub-structure in medicinal chemistry which contributes as a key part for different natural activities [2].
Which of the following is the pharmacological effect of benzimidazole?
Literature survey reveals that the various derivatives of benzimidazole have been synthesized for their pharmacological activities such as antimicrobial [3], anticancer [2], acetylcholinesterase [4], antiprotozoal [5], anti-inflammatory [6], analgesic [7], antihistaminic [8], antimalarial [9], antitubercular [10], anti …
Which of the following is the correct structure of benzimidazole *?
Benzimidazole | C7H6N2 – PubChem.
What are examples of benzimidazole?
Those of interest are mebendazole, flubendazole, fenbendazole, oxfendazole, oxibendazole, albendazole, albendazole sulfoxide, thiabendazole, thiophanate, febantel, netobimin, and triclabendazole.
What are benzimidazole derivatives?
Benzimidazole derivatives act by interfering with metabolic pathways. Parbendazole has been shown to exhibit a broad-spectrum Anthelmintic activity. This compound is the most potent of a series of substituted 2-amino derivatives, is active against a wide variety of animal nematodes [41].
What is the mechanism for the synthesis of benzimidazole?
Benzimidazole is produced by condensation of o-phenylenediamine with formic acid, or the equivalent trimethyl orthoformate: C6H4(NH2)2 + HC(OCH3)3 → C6H4N(NH)CH + 3 CH3OH. 2-substituted derivatives are obtained when the condensation is conducted with aldehydes in place of formic acid, followed by oxidation.
What is the mechanism of action of benzimidazoles?
Mechanism of action: Benzimidazoles interrupt parasite energy metabolism by binding to tubulin, thereby disrupting microtubular cell structure and preventing nutrient uptake and other functions.
Which are benzimidazole derivatives?
5.1. 2 Benzimidazole derivatives. Benzimidazole derivatives, particularly ABZ and MBZ are well known for their anti-Giardia potency, particularly as compared with other drugs used for routine treatment of giardiasis (i.e. lower IC50 against trophozoites in vitro and lower ED50 in experimental infections).
Which is commonly used benzimidazole?
Benzimidazole Derivatives
| Drug | Drug Description |
|---|---|
| Albendazole | A benzimidazole anthelmintic used to treat parenchymal neurocysticercosis and other helminth infections. |
| Mebendazole | A benzimidazole anthelmintic used to treat helminth infections. |
What type of reaction mechanism is benzimidazole?
Principle: The two Carbon-nitrogen bonds in benzimidazole when disconnected give o-phenylenediamine and formic acid. Therefore, synthesis of benziemidazole is affected by simply heating the o-phenylenediamine and formic acid together (condensation type of reaction).
What are the pharmacological properties of benzimidazole?
Benzimidazole is a heterocyclic aromatic organic compound. It is an important pharmacophore and a privileged structure in medicinal chemistry. This compound is bicyclic in nature which consists of the fusion of benzene and imidazole. Nowadays is a moiety of choice which possesses many pharmacological properties.
Why are benzimidazoles used as anthelmintics in animals?
Benzimidazoles are a chemical class of compounds with broad anthelmintic activity that are vastly used on livestock and pets to control all kinds of parasitic worms (helminths). Some veterinary benzimidazoles are also used as anthelmintics in human medicines.
When was the first benzimidazole licensed for human use?
The first benzimidazole to be developed and licensed for human use was thiabendazole in 1962. Further, a number of veterinary anthelminthics were developed and marketed, including parbendazole, fenbendazole, oxfendazole and cambendazole.