What should mechanical valve INR be?
In patients with mechanical heart valves in both the aortic and mitral position, a target INR of 3.0 (range 2.5 to 3.5) is suggested over a target INR of 2.5.
Do tissue heart valves require anticoagulation?
BACKGROUND: Heart valve replacement can be done with either a mechanical or bioprosthetic (tissue) prosthesis. Patients with mechanical heart valves are at increased risk for embolic stroke and thrombosis of the valve itself, and, therefore, require long-term anticoagulation.
What is INR goal for mechanical mitral valve?
Why does mitral valve have higher INR goal?
Current American and European clinical guidelines recommend a higher international normalized ratio (INR) for anticoagulant therapy after mechanical mitral valve replacement, because higher rates of thromboembolic complications were reported when the mechanical valve was in the mitral position, as compared to when the …
What is a good range for INR on warfarin?
In healthy people an INR of 1.1 or below is considered normal. An INR range of 2.0 to 3.0 is generally an effective therapeutic range for people taking warfarin for disorders such as atrial fibrillation or a blood clot in the leg or lung.
What is an INR goal?
For patients with tilting disk valves and bileaflet mechanical valves in the mitral position, therapy with warfarin to a target INR of 3.0 (range, 2.5-3.5) is recommended. For patients with caged ball or caged disk valves, therapy with warfarin to a target INR of 3.0 (range, 2.5-3.5) is recommended.
Why do mechanical valves need warfarin?
The main risk of a mechanical valve is that you can get blood clots that could cause a heart attack or stroke. To prevent blood clots, you will take a blood thinner called warfarin (such as Coumadin) every day.
Is warfarin an oral anticoagulant?
In the last fifty years the warfarin has been considered the oral anticoagulant of choice. However, its use is limited by a narrow therapeutic index and by a complex pharmacodynamics, which requires regular adjustments and monitoring of the dose.
What should INR be on warfarin?
An INR range of 2.0 to 3.0 is generally an effective therapeutic range for people taking warfarin for disorders such as atrial fibrillation or a blood clot in the leg or lung. In certain situations, such as having a mechanical heart valve, you might need a slightly higher INR.
Is 2.5 A good INR level?
In most situations the INR target is 2.5 (target range 2.0 – 3.0). This range is appropriate for the prophylaxis or treatment of venous thromboembolism and reduction of the risk of systemic embolism for people with atrial fibrillation and valvular heart disease.
Is INR 1.2 normal?
What is a critical INR level?
Normal and Critical Findings [8]For patients who are on anticoagulant therapy, the therapeutic INR ranges between 2.0 to 3.0. INR levels above 4.9 are considered critical values and increase the risk of bleeding.
What should the INR be for warfarin therapy?
For patients with tilting disk valves and bileaflet mechanical valves in the mitral position, therapy with warfarin to a target INR of 3.0 (range, 2.5-3.5) is recommended.
What is the target INR for valvular heart disease?
With mechanical valves in both the aortic and mitral position, a target INR of 3.0 (range 2.5 to 3.5) is recommended (Grade 2C recommendation)
When to use warfarin for mechanical heart valves?
“In patients with mechanical prosthetic heart valves who have systemic embolism despite a therapeutic INR, we suggest the addition of ASA (50 to 100 mg/d) if not previously provided and/or upward titration of warfarin therapy to achieve a higher target INR.
What is the target INR for VKA therapy?
With mechanical aortic valve, VKA therapy with a target INR of 2.5 if no risk factors (atrial fibrillation, prior thromboembolism, left ventricular dysfunction, or hypercoagulable state) are present (Class I recommendation; Level of evidence: B) VKA therapy with a target INR of 3.0 after: