What class drug is mitoxantrone?
Mitoxantrone injection is in a class of medications called anthracenediones. Mitoxantrone treats MS by stopping certain cells of the immune system from reaching the brain and spinal cord and causing damage. Mitoxantrone treats cancer by stopping the growth and spread of cancer cells.
What is the generic name for mitoxantrone?
DHAD is another name for Mitoxantrone. In some cases, health care professionals may use the trade name Novantrone or other name DHAD when referring to the generic drug name Mitoxantrone. Drug type: Novantrone is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug.
What is mitoxantrone hydrochloride?
The hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisomerase II, resulting in DNA strand breaks and inhibition of DNA repair.
What is the use of mitoxantrone?
Mitoxantrone is used to treat leukemia and other cancers. It is also used to treat multiple sclerosis. It belongs to a class of drugs known as anthracenediones and works by slowing or stopping the growth of certain cells (including cancer cells and cells that affect the body’s natural defenses).
How is mitoxantrone administered?
Mitoxantrone should be given slowly into a freely flowing intravenous infusion. Mitoxantrone must not be given subcutaneously, intramuscularly, or intra-arterially. There have been reports of local/regional neuropathy, some irreversible, following intra-arterial injection.
How does mitoxantrone work in the body?
Mitoxantrone appears to work by suppressing the body’s immune system for the period of treatment, depleting the number of cells that are attacking the myelin around nerves. This effectively gives the body a chance to ‘restart’ and sort out what has gone wrong with the immune system.
How long does it take mitoxantrone to work?
For treating MS and prostate cancer, it usually takes 5 to 15 minutes to infuse. People with acute nonlymphocytic leukemia may need to stay in the hospital for treatment, as the drug is generally given as part of a combination therapy.
Is mitoxantrone an antibiotic?
Mitoxantrone is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. Mitoxantrone is classified as an “antitumor antibiotic.” (For more detail, see “How Mitoxantrone Works” section below).
How long does mitoxantrone stay in your system?
Your urine may take on a bluish-green color for a maximum of 48 hours after having the treatment. This is because of the color of mitoxantrone.
Does mitoxantrone cause hair loss?
Temporary hair thinning/loss may occur. Normal hair growth should return after treatment has ended. This medication may cause your urine to turn blue-green. The white part of your eyes may also turn a bluish color.
How long does mitoxantrone take to work?
What is the hydrochloride salt of anthracenedione?
Mitoxantrone Hydrochloride is the hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication.
How is mitoxantrone an anthracenedione antibiotic?
Mitoxantrone is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisomerase II, resulting in DNA strand breaks and inhibition of DNA repair. Mitoxantrone is less cardiotoxic compared to doxorubicin.
What is the role of mitoxantrone in the body?
Mitoxantrone is a dihydroxyanthraquinone that is 1,4-dihydroxy-9,10-anthraquinone which is substituted by 6-hydroxy-1,4-diazahexyl groups at positions 5 and 8. It has a role as an antineoplastic agent and an analgesic.
What are the side effects of taking mitoxantrone?
Mitoxantrone therapy is often accompanied by mild to moderate elevations in serum aminotransferase levels, but in typical doses it rarely causes clinically apparent, acute liver injury. Mitoxantrone is a dihydroxyanthraquinone that is 1,4-dihydroxy-9,10-anthraquinone which is substituted by 6-hydroxy-1,4-diazahexyl groups at positions 5 and 8.