What bacteria does daptomycin cover?
Daptomycin is a cyclic lipopeptide antibiotic derived from the organism Streptomyces roseosporus. Daptomycin is used to treat various bacterial infections caused by Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE).
What class of antibiotic is daptomycin?
Daptomycin is the first member of a new class of bactericidal antibiotics, the cyclic lipopeptides. In September 2003, daptomycin was approved for the treatment of Gram-positive infections associated with complicated skin and skin structure infections.
Is daptomycin a broad spectrum antibiotic?
Purpose: : Daptomycin is a broad-spectrum antibiotic for Gram-positive bacteria, including those with vancomycin resistance. The rapid and complete bactericidal activity, long half-life, minimal resistance, and lack of cell-wall lysis with bacterial death compare favorably to vancomycin.
What does Vanc cover?
Vancomycin, a useful bactericidal antibiotic for selective clinical infections, is the therapy of choice for serious staphylococcal infections when the penicillins and cephalosporins cannot be used. The antibacterial spectrum of vancomycin also covers other gram-positive cocci and bacteria and gram-negative cocci.
Does daptomycin cover MRSA?
Daptomycin Is Highly Effective for Methicillin-resistant Staphylococcus Aureus (MRSA) Infections That Have a High Vancomycin MIC. Study results show that daptomycin cleared MRSA infections within four days of treatment in 80% of patients and was particularly effective against extra-vascular infections.
How is daptomycin dosed?
Dosage In Adults For cSSSI Administer CUBICIN 4 mg/kg to adult patients intravenously in 0.9% sodium chloride injection once every 24 hours for 7 to 14 days.
What is polymyxin B target?
Polymyxins have bactericidal action against Gram-negative bacteria, including Pseudomonas species, but are inactive against Gram-positive bacteria.
Does daptomycin cover Enterococcus faecalis?
Abstract. Daptomycin is one of the few treatment options for infections caused by enterococci that are resistant to ampicillin and vancomycin, such as vancomycin-resistant Enterococcus faecium.
Does Bactrim cover MRSA?
Patients with fever or other systemic symptoms are also usually treated with antimicrobial agents. Trimethoprim/sulfamethoxazole (TMP/SMX; Bactrim, Septra) is the agent most commonly used to treat adults with community-acquired MRSA infections in the United States.
Does gentamicin cover MRSA?
Although gentamicin (GEN) is usually susceptible against CA-MRSA, GEN is rarely considered for treatment as monotherapy.
Is daptomycin related to vancomycin?
Daptomycin, a lipopeptide antibiotic, is approved by the US Food and Drug Administration for the treatment of S. aureus bacteremia and is considered a reasonable alternative to vancomycin. The efficacy of daptomycin has been demonstrated in an open-label randomized clinical trial by Fowler et al.
What kind of infections can daptomycin be used for?
Using a variety of antibiotic-resistant and -sensitive Gram-positive bacteria, daptomycin eradicated infections in the blood, muscle, kidney, heart and bone tissues of animals. 35 – 41 These results show promise for daptomycin therapy for further clinical indications.
How long does it take for Daptomycin to clear bacteremia?
After daptomycin plus ceftaroline was started, the median time to bacteremia clearance was 2 days (range, 1-6 days). In vitro studies showed ceftaroline synergy against MRSA and enhanced MRSA killing by cathelicidin LL-37 and neutrophils.
How long should you take daptomycin for a MRSA infection?
For adults with complicated bacteremia (positive blood culture results without meeting criteria for uncomplicated bacteremia), four to six weeks of therapy is recommended, depending on the extent of infection. Some experts recommend higher dosages of daptomycin (8 to 10 mg per kg intravenously once per day).
Which is better for staphylococcal bacteremia ceftaroline or daptomycin?
Ceftaroline offers dual benefit via synergy with both daptomycin and sensitization to innate host defense peptide cathelicidin LL37, which could attenuate virulence of the pathogen. Ceftaroline plus daptomycin may be an option to hasten clearance of refractory staphylococcal bacteremia.