What phenothiazines are used as antiemetics?
Phenothiazines, such as prochlorperazine (Compazine), thiethylperazine (Torecan), promethazine (Phenergan), and chlorpromazine (Thorazine) act predominantly as dopamine receptor antagonists, but they also have anticholinergic and antihistaminic blocking effects.
What are the examples of anti emetics?
Some antiemetics that people take to combat nausea from chemotherapy include:
- aprepitant (Emend)
- dexamethasone (DexPak)
- dolasetron (Anzemet)
- granisetron (Kytril)
- ondansetron (Zofran)
- palonosetron (Aloxi)
- prochlorperazine (Compazine)
- rolapitant (Varubi)
Which medication is used as an anti emetic?
Dopamine antagonists, such as metoclopramide (Reglan), domperidone (Motilium), and chlorpromazine, are amongst the most commonly used antiemetics, and they’re also indicated for postoperative nausea and motion sickness.
What are phenothiazines used for?
Phenothiazines are used to treat serious mental and emotional disorders, including schizophrenia and other psychotic disorders. Some are used also to control agitation in certain patients, severe nausea and vomiting, severe hiccups, and moderate to severe pain in some hospitalized patients.
What are examples of phenothiazines?
Examples of phenothiazines include: chlorpromazine (brand name: Thorazine), fluphenazine (Duraclon), mesoridazine (Serentil), perphenazine (Etrafon and Trilafon), prochlorperazine (Compazine), promazine (Robinul and Anectine), thioridazine (Mellaril), trifluoperazine (Stelazine) and triflupromazine (Robinul).
Are antihistamines phenothiazines?
Phenothiazine (FEE-noe-THYE-a-zeen)-derivative antihistamines are used to relieve or prevent the symptoms of hay fever and other types of allergy. They work by preventing the effects of a substance called histamine, which is produced by the body. Histamine can cause itching, sneezing, runny nose, and watery eyes.
Is loperamide an antiemetic?
Loperamide is an antidiarrheal agent, which decreases intestinal movement. As such, when combined with other antimotility drugs, the risk of constipation is increased. These drugs include other opioids, antihistamines, antipsychotics, and anticholinergics.
Is Benadryl an antiemetic?
Benadryl is a prescription medicine used to treat the symptoms of allergic reactions, insomnia, and motion sickness. Benadryl may be used alone or with other medications. Benadryl belongs to a class of drugs called Antihistamines, 1st Generation, Antiemetic Agents.
Which tablet is best for vomiting?
Over-the-counter (OTC) medications to stop vomiting (antiemetics) such as Pepto-Bismol and Kaopectate contain bismuth subsalicylate. They may help protect the stomach lining and reduce vomiting caused by food poisoning. Buy Pepto-Bismol on Amazon today.
Which anti emetic is safe in pregnancy?
| Table 1: Antiemetics suitable for use in pregnancy (in order of preference)3,4,10 | |
|---|---|
| Medication | Dose |
| Cyclizine | 50 mg three times daily |
| Promethazine | 25 mg at bedtime, increased to maximum 100 mg daily in divided doses |
| Ondansetron (hyperemesis gravidarum) | 4 – 8 mg two to three times daily |
Does phenothiazines cause weight gain?
Adverse Effects Extrapyramidal symptoms, including dystonia, parkinsonism, akathisia, and tardive dyskinesia. Weight gain.
How do phenothiazines work?
What are Phenothiazine antiemetics? Phenothiazine antiemetics are a type of medicine that may be used to relieve nausea and vomiting. They work by inhibiting dopamine, muscarinic and histamine (H1) receptors generally in the vomiting center and chemoreceptor trigger zone.
How does phenothiazine work as an antiemetic?
Phenothiazines are the most commonly prescribed antiemetics (Table 25.1 ). They exert an antiemetic effect by blocking dopamine-2 and 5-HT receptors in the chemoreceptor trigger zone, as well as having weak histamine-1 and muscranic-1 receptor blocking activity.
Which is the most used phenothiazine in the world?
The most commonly used phenothiazines as antiemetics are promethazine and prochlorperazine. Chlorpromazine and perphenazine are first generation antipsychotic medications for bipolar disorder and schizophrenia, and they are used much less as antiemetic agents.
Are there any side effects to taking phenothiazine?
These drugs have antipsychotic and, often, antiemetic properties, although they may also cause severe side effects such as extrapyramidal symptoms (including akathisia and tardive dyskinesia ), hyperprolactinaemia, and the rare but potentially fatal neuroleptic malignant syndrome, as well as substantial weight gain.
How is phenothiazine used in the treatment of schizophrenia?
Descriptions Phenothiazines are used to treat serious mental and emotional disorders, including schizophrenia and other psychotic disorders. Some are used also to control agitation in certain patients, severe nausea and vomiting, severe hiccups, and moderate to severe pain in some hospitalized patients.