What do you mean by network motifs?

What do you mean by network motifs?

Network Motifs. Network motifs have been introduced by the group of Uri Alon (Milo et al., 2002). They are defined as small patterns of interconnections occurring in complex networks at numbers that are significantly higher than those in randomized networks (Milo et al., 2002).

Which one is an overrepresented motif in biological gene regulatory networks?

Again, biological gene networks have been found containing some of these motifs (16), the bifan motif being perhaps the most prominent. None of the motifs “B” to “F” were overrepresented in the networks satisfying multistability.

What is network motifs in biology?

Network motifs are statistically overrepresented sub-structures (sub-graphs) in a network, and have been recognized as ‘the simple building blocks of complex networks’. Study of biological network motifs may reveal answers to many important biological questions.

How do you explain a motif?

A motif is a literary term that is an idea, object, or concept that repeats itself throughout a text. A motif gives clues to theme or reinforces ideas an author wants to emphasize. A motif generally reinforces the theme of the text. A motif must be repeated throughout a text to be considered a motif.

How are network motifs discovered?

Network motif discovery is the process of finding subgraphs whose frequency is statistically significant within a complex network. The primary tasks involved in this process are frequency computation, random graph generation, statistical significance measure, subgraph isomorphism etc.

What are Graph motifs?

Graph motifs are small connected subgraphs with a well-defined structure. These functions search a graph for various motifs.

What is a feedforward loop?

In gene regulation, the feedforward loop (FFL) – which consists of an input gene (X) that regulates an intermediate gene (Y), while both X and Y regulate an output gene (Z) – is one such overrepresented motif [1, 3,4,5,6].

What is a motif in literature?

A motif is a recurring element in a literary work, meaning the idea or image occurs again and again. When related images repeat to enhance or bring attention to an idea, you know you’ve identified the story’s motif.

How do you identify motifs in literature?

A motif is a recurring narrative element with symbolic significance. If you spot a symbol, concept, or plot structure that surfaces repeatedly in the text, you’re probably dealing with a motif. They must be related to the central idea of the work, and they always end up reinforcing the author’s overall message.

What are motifs in graphs?

Network motifs are sub-graphs that repeat themselves in a specific network or even among various networks. Each of these sub-graphs, defined by a particular pattern of interactions between vertices, may reflect a framework in which particular functions are achieved efficiently.

What is the difference between feedback and feedforward?

What are feedback and feedforward? When an employee receives feedback, they get information about how they’re presently performing. Feedforward is the reverse exercise of feedback. It’s the process of replacing positive or negative feedback with future-oriented solutions.

What is the difference between feedforward and feedback control?

Feedforward control measures one or more inputs of a process, calculates the required value of the other inputs and then adjusts it. Feedback control measures the output of a process, calculates the error in the process and then adjusts one or more inputs to get the desired output value.

How are gene regulatory networks control developmental processes?

Gene regulatory networks control developmental, homeostatic, and disease processes by governing precise levels and spatio-temporal patterns of gene expression. Determining their topology can provide mechanistic insight into these processes.

How does iregulon reverse engineer the gene regulatory network?

We developed a computational method, called iRegulon, to reverse-engineer the transcriptional regulatory network underlying a co-expressed gene set using cis -regulatory sequence analysis. iRegulon implements a genome-wide ranking-and-recovery approach to detect enriched transcription factor motifs and their optimal sets of direct targets.

What does each regulatory interaction of a transcription factor represent?

Each regulatory interaction represents the binding of the transcription factor to a specific DNA binding site near its target gene.

Why are TFS important to the regulation of gene expression?

Because TFs play key roles in gene expression, they are often considered the master regulators of cellular processes. Thus, the mapping and characterization of their regulon (all the target genes of a TF) can provide crucial insight into the biological processes they control [6], [7].