What is the most serious adverse effect of tizanidine therapy?

What is the most serious adverse effect of tizanidine therapy?

Tell your doctor right away if you have any serious side effects, including: fainting, mental/mood changes (such as hallucinations), slow/irregular heartbeat, vision changes (such as blurred vision). Tizanidine has rarely caused very serious (rarely fatal) liver disease.

Is it bad to take tizanidine every night?

You should take tizanidine only for daily activities that require relief from muscle spasms. Do not take more than three doses (36 mg) in a 24-hour period. Too much of this medicine can damage your liver.

How long after taking Cipro can I take tizanidine?

Conclusions: Ciprofloxacin greatly elevates plasma concentrations of tizanidine and dangerously potentiates its hypotensive and sedative effects, mainly by inhibiting its CYP1A2-mediated metabolism, at least when administered 1 hour before tizanidine.

Is tizanidine bad for kidneys?

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of tizanidine in the elderly. However, elderly patients are more likely to have kidney problems, which may require caution in patients receiving this medicine.

What happens if you take tizanidine and Cipro together?

Interactions between your drugs Using ciprofloxacin and tiZANidine is not recommended. Taking these drugs together can cause symptoms of drowsiness, dizziness, slurred speech, confusion, weakness, or low blood pressure. Do not drive or operate machinery until you know how your body will respond to these drugs.

Is tizanidine good for sleep?

We consider that tizanidine has direct effects on the induction of sleep, and promotes muscular relaxation bringing about good sleep. We conclude that tizanidine is useful for the treatment of refractory sleep disturbance in spastic quadriplegic patients.

What medications Cannot be taken with tizanidine?

Using tizanidine with the following drugs can cause excessive sedation (drowsiness): benzodiazepines such as alprazolam, lorazepam, or diazepam. opioids such as morphine, methadone, or oxycodone. certain antidepressants such as amitriptyline, nortriptyline, or protriptyline.

Does tizanidine make you tired the next day?

Your dose will then be increased at 3- to 4-day intervals until you are on a dose that suits your condition. Tizanidine can make you feel sleepy or dizzy. It can slow your reactions, so please take care if you are using tools or machines, or if you drive.

How long does tizanidine work for?

The effects of tizanidine peak within 1-2 hours and start to wear off within 3 to 6 hours. Because of this short duration of effect, tizanidine may be dosed on an “as needed” basis during times when muscle spasms are at their most severe.

Are there any side effects to taking tizanidine?

More common 1 Dizziness or lightheadedness, especially when getting up from a lying or sitting position. 2 drowsiness. 3 dry mouth. 4 fatigue. 5 sleepiness. 6 (more items)

Do you have to take tizanidine with or without food?

Do not use more medicine or use it more often than your doctor tells you to. • You may take this medicine with or without food, but you should take it the same way every time. Tizanidine works differently depending on whether you take it on an empty stomach or a full stomach.

What kind of spasticity does tizanidine hydrochloride treat?

Tizanidine Hydrochloride (Zanaflex) is FDA approved to treat reversible spasticity associated with multiple sclerosis or spinal cord lesions. The medicine comes in 2 and 4 mg tablets.

How often should you take tizanidine hydrochloride at night?

The usual dose is 8-36 mg a day divided into 3 doses per day but the dose can vary depending on how well it works for you and your tolerance of the medication. The initial starting dose is 4 mg at night. You should add another 4 mg tablet after 5-7 days and then wait 5-7 more days before adding further 4 mg tablets, etc.

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