What are the indication for splenectomy?
Splenectomy is indicated to help control or stage the underlying disease in cases of splenomegaly. These diseases can include hereditary spherocytosis, immune thrombocytopenia (ITP) or autoimmune hemolysis.
What is the most common indication for splenectomy?
Splenomegaly (see the image below) is observed in conditions such as idiopathic (immune) thrombocytopenic purpura (ITP), thrombotic thrombocytopenic purpura (TTP), and hereditary spherocytosis. Of these, ITP is the most common indication for elective splenectomy.
When is splenectomy needed for SCD?
Necessary splenectomy is done for a variety of reasons including acute splenic sequestration crisis, hypersplenism, massive splenic infarction and splenic abscess [3]. Splenic complications of SCD are associated with an increased morbidity and sometimes it may lead to mortality.
What is elective splenectomy?
An elective splenectomy is usually recommended for certain problems with your blood and to remove the life-threatening risk of your spleen rupturing.
What are the four main functions of the spleen?
The four most important normal functions of the spleen are as follows:
- Clearance of microorganisms and particulate antigens from the blood stream.
- Synthesis of immunoglobulin G (IgG), properdin (an essential component of the alternate pathway of complement activation), and tuftsin (an immunostimulatory tetrapeptide)
What are the functions of spleen?
What does the spleen do?
- Stores blood.
- Filters blood by removing cellular waste and getting rid of old or damaged blood cells.
- Makes white blood cells and antibodies that help you fight infection.
- Maintains the levels of fluid in your body.
- Produces antibodies that protect you against infection.
Why does the spleen enlarged in sickle cell anemia?
Sickle cells can block the blood vessels leading out of the spleen. When this happens, blood stays in the spleen instead of flowing through it. This causes the spleen to get bigger, and the blood counts to fall.
How is splenic sequestration diagnosed?
Sequestration events are primarily a clinical diagnosis when an acute enlargement of the spleen accompanies signs of anemia such as pallor, fatigue, and tachycardia. The evaluation consists of a careful physical exam and a CBC to assess for the degree of anemia.
When is a splenectomy an elective procedure?
Elective splenectomy in adults is often performed after failure of conservative treatment in patients with hematologic, neoplastic, or autoimmune disorders. The indication to perform a splenectomy should be discussed in an interdisciplinary team and the surgeon should not make the decision on his own.
What are the 5 functions of the spleen?
Your spleen:
- Stores blood.
- Filters blood by removing cellular waste and getting rid of old or damaged blood cells.
- Makes white blood cells and antibodies that help you fight infection.
- Maintains the levels of fluid in your body.
- Produces antibodies that protect you against infection.
What are 3 functions of the spleen?
What are the functions of the spleen?
- Clearance of microorganisms and particulate antigens from the blood stream.
- Synthesis of immunoglobulin G (IgG), properdin (an essential component of the alternate pathway of complement activation), and tuftsin (an immunostimulatory tetrapeptide)
What are the two main functions of the spleen?
The spleen plays multiple supporting roles in the body. It acts as a filter for blood as part of the immune system. Old red blood cells are recycled in the spleen, and platelets and white blood cells are stored there. The spleen also helps fight certain kinds of bacteria that cause pneumonia and meningitis.