What is culprit shock trial?
The Culprit Lesion Only PCI versus Multivessel PCI in Cardiogenic Shock (CULPRIT-SHOCK) trial was designed to test the hypothesis that PCI of the culprit lesion only, with the option of staged revascularization of nonculprit lesions, would result in better clinical outcomes than immediate multivessel PCI among patients …
What does culprit lesion mean?
Background: The term “culprit lesion” is used to designate the coronary stenosis responsible for the symptoms of the pa- tient with coronary artery disease. Its detection is essential when partial revascularization is contemplated.
What is the shock trial?
The role of primary PCI in cardiogenic shock was evaluated in the 1999 SHould we emergently revascularize Occluded Coronaries for Cardiogenic shocK (SHOCK) trial, which randomized 302 patients in cardiogenic shock after acute MI to a strategy of early revascularization (PCI or CABG within 12 hours of diagnosis) or to …
What is a nstemi?
Non-ST-elevation myocardial infarction (NSTEMI) is a type of [“heart attack”: link to new heart attack copy] involving partial blockage of one of the coronary arteries, causing reduced flow of oxygen-rich blood to the heart muscle.
Should we emergently Revascularize occluded coronaries for cardiogenic shock shock trial?
The SHOCK (Should We Emergently Revascularize Occluded Coronaries for Cardiogenic Shock) Trial demonstrated a nonsignificant reduction in 30-day mortality (56% vs 47%) when early revascularization (ERV) was compared with a strategy of initial medical stabilization (IMS), with a larger difference between the groups at 6 …
What is takotsubo?
Takotsubo cardiomyopathy (TCM) is generally a short-term (temporary) type of heart condition. It can be triggered by an intense emotional or physical stress. It causes sudden chest pain or shortness of breath. The symptoms of TCM can look like a heart attack.
What do Tearblast arrows do?
Tearblast Arrows are an arrow type compatible only with the Sharpshot Bow. They emit sonic blasts after latching on target, inflicting huge Tear damage. It utilizes a powerful compressed air blast to easily strip armor and components off machines.
What was the outcome of the culprit PCI trial?
Based on CULPRIT-PCI trial results, 2018 ESC/EACTS Guidelines on myocardial revascularization downgraded immediate multivessel PCI in cardiogenic shock to Class IIIB recommendation [2]. Class IIIB means that the procedure is not useful and may be harmful, based on the evidence from a single randomized trial.
How many patients were involved in the culprit shock clinical trial?
It was a multicenter randomized trial involving 706 patients who were randomized to either immediate PCI of the culprit lesion only with option for staged PCI of non-culprit lesions or immediate multivessel PCI.
What are the endpoints of culprit lesion only PCI?
The trial randomized 706 patients to either culprit lesion only PCI, with the option of staged revascularization, or immediate multivessel PCI. The primary efficacy endpoint was 30-day mortality or severe renal failure requiring renal replacement therapy. Safety endpoints included assessment of bleeding and stroke.
Which is better complete or culprit only revascularization?
Cardiovascular death, MI, or ischemia-driven revascularization: 8.9% with complete revascularization vs. 16.7% with culprit-only revascularization (p < 0.001) Major bleeding: 2.9% with complete revascularization vs. 2.2% with culprit-only revascularization (p = 0.15)