What is quinone imine?
1 : a colorless crystalline compound O=C6H4=NH regarded as derived from quinone (see quinone sense 1a) by replacement of one oxygen atom by the imino group but made by oxidation of para-aminophenol. — called also p-benzoquinone imine, p-quinonimine.
Why is quinone imine toxic?
According to their reactivity, quinones and quinone imines react as Michael’s acceptors with cell proteins or DNA and, in this way, cause damage to the cells.
What is quinoneimine dye?
a group of dyes that are derivatives of para-quinone imine (I) or para-quinone diimine (II), in which the hydrogen atom of an imine group is replaced by an aromatic residue containing an NH2 or OH– group.
What is Trinder method?
The Trinder method is used to determine glucose concentration only, (Lott et al, 1975). The Trinder method, ‘is based on two sequential enzymatic reactions, the first one involves the oxidation of glucose to gluconic acid and H2O2,’ (Casabnon et al, 2005). This reaction is catalysed by the enzyme Glucose oxidase.
How imine is formed?
Imine formation is a reversible process that starts with the nucleophilic addition of a primary amine to the carbonyl group of an aldehyde or ketone. Acid protonation of the carbinolamine oxygen converts it into a better leaving group which is subsequently eliminated as water producing an iminium ion.
How do you make an imine?
Imines are the nitrogen analogues of aldehydes and ketones, containing a C=N bond instead of a C=O. bond. They are formed through the dehydration reaction of an aldehyde or ketone with an amine. Imines derived from aldehydes are sometimes called aldimines, imines derived from ketones are sometimes called ketimines.
Where is NSAIDs metabolized?
Ibuprofen and other NSAIDs rarely affect the liver. Unlike acetaminophen (Tylenol), most NSAIDs are absorbed completely and undergo negligible liver metabolism. In other words, the way NSAIDs are metabolized makes liver injury ( hepatotoxicity) very rare.
What is God Pod method?
The GOD-POD method is linear (up to 500 mg/dl), sensitive (detection limit 0.3 mg/dl), simple (requires 10 microlitre of sample to be incubated for 30 minutes with single reagent at room temperature) and requires simple instrumentation (the absorbance to be read between 505 nm to 550 nm).
What was the synthesis of quinone imine ketals?
An interesting report of the synthesis of quinone imine was the oxidative cyclisation of phenylalkylazide with phenyliodine (III) bis (trifluoroacetate) (PIFA) and trimethylsilyl trifluoromethanesulphonate (TMSOTf).139 Synthesis of quinine imine ketals.
How is quinone imine used as a surrogate coupling partner?
Quinone imine ketal 199 was used as the arene surrogate coupling partner, while Hantzsch ester 200 facilitated the reduction. The indoline products, which bear a new quaternary carbon center, were obtained in good yields with excellent diastereoselectivity and enantioselectivity (14AG (I)13912). Sign in to download full-size image
How is quinone imine a strong oxidizing agent?
The quinone-imines produced were shown to be strong oxidizing agents spontaneously converting NADH to NAD +. Due to their electrophilic nature, the quinone-imine compounds are susceptible to covalent attack by nucleophiles, and the 9-hydroxy-2-methylellipticinium derivative was shown to bind covalently to bovine serum albumin.
How is NQO1 involved in the reduction of quinones?
NQO1 is involved in the reduction of a number of quinones and quinone-imines, bypassing the semiquinone intermediates, and thus formation of superoxide ( Scheme 3.3 ), via two-electron reduction. Hence, it is termed as antioxidant or cytoprotective enzyme [35].