What is Higuchi model in drug release?

Higuchi model is given by the equation: ft = Q = A√ where, Q is the amount of drug released in time t per unit area A, C is the drug initial concentration, Cs is the drug solubility in the matrix media and D is the diffusivity of the drug molecules (diffusion coefficient) in the matrix substance.

How is drug release kinetics calculated?

The fundamental principle for evaluation of the kinetics of drug release was offered by Noyes and Whitney in 1897 as the equation (10): dM/dt = KS (Cs с Ct) (1) where M, is the mass transferred with respect to time, t, by dissolution from the solid particle of instanta- neous surface, S, under the effect of the …

What is kinetic drug release?

“It is a process by which a drug leaves a drug product. & is subjected to ADME & eventually becoming. available for pharmacological action.” It involves the study of drug release rate, dissolution.

What is Hixson Crowell cube root law?

The Hixson-Crowell cube root law describes the release from system where there is a change in surface area and diameter of the particles or tablets [15,16]. The applicability of all of these equations was tested in this work. The dissolution data obtained for all formulations at pH.

What is the Higuchi model?

The Higuchi model describes the release rate of solute from the matrix where loading of solute exceeds its solubility in the matrix into the surrounding fluid (Paul, 2011) . In contrast, the Korsmeyer-Peppas model describes solute release from the matrix when more than one mechanism is involved (Bruschi, 2015). …

What is Peppas model?

Korsmeyer-Peppas was a simple model known as “Power law” describing drug release from a polymeric system. Korsmeyer-Peppas model (1) describe some release mechanisms simultaneously such as the diffusion of water into the matrix, swelling of the matrix and dissolution of the matrix [12].

What is Peppas plot?

Korsmeyer’s-Peppa’s model  A simple relationship which described drug release from a polymeric system equation was derived by Korsmeyer-Peppa in 1983  To understand the mechanism of drug release and to compare the release profile differences among these matrix formulations ,the percent drug released time versus time …

What does zero-order kinetics mean?

Zero-order kinetics is described when a constant amount of drug is eliminated per unit time but the rate is independent of the concentration of the drug.

What is Hixson Crowell?

Hixson Crowell’s cube root equation is a mathematical model used to describe powder dissolution or drug release from specific formulations. The shape (drug particles , drug dosage form…) is spherical and size will decrease as the system dissolves.

What is mathematical model in drug design?

Drug development is the process of bringing a new pharmaceutical drug to the market once a lead compound has been identified through the process of drug discovery [ 6 ]. Mathematical model: A mathematical model is a description of a system using mathematical concepts and language.

What is the Higuchi equation for drug release?

HIGUCHI’S EQUATION / MODEL The equation for Higuchi’s For drug release through matrix Q = KH t1/2 0r Mt / M0 = kt 1/2 Q = cumulative amount of drug release at time “t” KH = Higuchi constant t = time in hours • Amount of drug released Vs square root of time.

What is the equation for drug release kinetics?

What are the benefits of the Higuchi equation?

The major benefits of this equation include the possibility to: (i) facilitate device optimization, and (ii) to better understand the underlying drug release mechanisms.

What is the significance of Higuchi’s model?

• Diclofenac gel. What is the significance HIGUCHI’S EQUATION / MODEL ……. It describes the drug release as a diffusion process based on the Fick’s law which is square root time dependent. 164/19/2016 sagar kishor savale 17.