Is mustard gas an alkylating agents?

Is mustard gas an alkylating agents?

Sulfur mustard is also an alkylating agent that damages the cells within the bone marrow that are necessary for making blood cells; this affects the body’s immune system.

Why nitrogen mustards are called alkylating agents?

Nitrogen mustards are cytotoxic organic compounds with the chloroethylamine (Cl(CH2)2NR2) functional group. Although originally produced as chemical warfare agents, they were the first chemotherapeutic agents for treatment of cancer. Nitrogen mustards are nonspecific DNA alkylating agents.

What does nitrogen mustard do to DNA?

Alkylating agents (nitrogen mustards and ethylenimines) act by transferring alkyl groups to DNA in the N-7 position of guanine during cell division. Normal synthesis is prevented because of either DNA strand breakage or cross-linking of the two strands.

What is the mutation effect of nitrogen mustard?

Nitrogen mustards are genotoxic in virtually every assay, and produce a wide array of mutations, including base substitutions at both G.C and A.T base pairs, intragenic as well as multilocus deletions, and chromosomal rearrangements.

Is bendamustine a nitrogen mustard?

Bendamustine (BM) is a nitrogen mustard used in the treatment of chronic lymphocytic leukemia (CLL) and non-Hodgkin’s lymphoma. It belongs to the family of drugs called alkylating agents.

What drug class is nitrogen mustard?

Drug type: Nitrogen Mustard is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. Nitrogen Mustard is classified as an “alkylating agent.” (For more detail, see “How this drug works” section below).

Which is an alkylating agent under nitrogen mustard?

There are several types of alkylating agents. Mustard gas derivatives: Mechlorethamine, Cyclophosphamide, Chlorambucil, Melphalan, and Ifosfamide. Ethylenimines: Thiotepa and Hexamethylmelamine. Alkylsulfonates: Busulfan.

How are nitrogen mustard derivatives an alkylating agent?

Background & objective: Nitrogen mustard derivatives form one of the major classes of anti-cancer agents in USFDA approved drugs list. These are polyfunctional alkylating agents which are distinguished by a unique mechanism of adduct formation with DNA involving cross-linking between guanine N-7 of one strand of DNA with the other.

What kind of drug is a nitrogen mustard?

Abstract Background & objective: Nitrogen mustard derivatives form one of the major classes of anti-cancer agents in USFDA approved drugs list.

Are there any side effects to nitrogen mustard?

Important things to remember about the side effects of Nitrogen Mustard: Most people do not experience all of the side effects listed. Side effects are often predictable in terms of their onset and duration. Side effects are almost always reversible and will go away after treatment is complete.

Which is an example of an alkylating agent?

Alkylating agents are further classified into nitrogen mustard, ethylenimines, methanesulfonates, nitrosourea, triazene etc. Exploration in the area of tumor biology has led to the elucidation of the mechanism of action for antineoplastic agents and also provides a basis for more rational design of new drugs.