What causes Lobomycosis?
Lobomycosis, also known as keloidal blastomycosis or Jorge Lobo disease, is caused by the fungus Lacazia loboi. The infection is restricted to tropical areas of Central and South America and is hyperendemic in areas of Brazil. The organism is known to cause disease in humans and in dolphins.
Why does diabetes cause mucormycosis?
In the diabetic ketoacidosis patient, there is an increased risk of mucormycosis caused by Rhizopus oryzae as these organisms produce the enzyme ketoreductase, which allows them to utilize the patient’s ketone bodies.
What is Loboa Loboi?
The etiologic agent of Jorge Lobo’s disease (lacaziosis), Lacazia loboi is an uncultivated fungal pathogen of humans and dolphins causing cutaneous and subcutaneous infections and, rarely, visceral involvement. This anomalous pathogen is restricted to Mexico, Central America, and South America.
What is the causative agent of lobomycosis?
Lobomycosis is a chronic fungal infection of the skin and subcutaneous tissue that primarily occurs in tropical climates of Latin America. The causative organism is Lacazia loboi (formerly Loboa loboi), a dimorphic fungus found in soil, vegetation, and water.
How is lobomycosis treated?
Combination itraconazole and clofazimine has been used in the treatment of lobomycosis on the face, with no relapse after 3-year follow up. Patients with lobomycosis and concurrent leprosy respond to multibacillary therapy, with reduction of pruritus and the size of mycotic nodules.
Which of the following are etiologic agents of Chromoblastomycosis?
Chromoblastomycosis is a disease caused by one of a group of dark-walled fungi (phaeohyphomycetes). The most common etiologic agent is Fonsecaea pedrosoi. Other fungi that cause this disease include Cladophialophora carrionii, Phialophora verrucosa, and Rhinocladiella aquaspersa.
Where is mucormycosis most common?
Rhinocerebral (sinus and brain) mucormycosis is an infection in the sinuses that can spread to the brain. This is most common in people with uncontrolled diabetes and in people who have had a kidney transplant.
Are diabetics more prone to mucormycosis?
It seems that type 2 diabetes is more susceptible to mucormycosis. Clinical and experimental data clearly demonstrate that individuals who lack phagocytes or have impaired phagocytic function are at higher risk of mucormycosis.
What is the causative agent of Lobomycosis?
How is Lacazia Loboi transmitted?
Cases of lobomycosis have been reported only in dolphins and humans. Its prevalence is higher among men who are active in the forest, such as rubber tappers, bushmen, miners, and Indian men. It is recognized that the traumatic implantation of the fungus on the skin is the route by which humans acquire this infection.
How does lobomycosis get into the human body?
Lobomycosis is caused by the fungus Lacazia loboi. This fungus is present in the soil, vegetation, and water, in the forests of certain Central and South American regions The fungus gains entry into the skin through a break/cut on the skin.
Are there any known risk factors for lobomycosis?
The following are some known risk factors for developing Lobomycosis: It is important to note that having a risk factor does not mean that one will get the condition. A risk factor increases ones chances of getting a condition compared to an individual without the risk factors. Some risk factors are more important than others.
What was the first case report of lobomycosis?
The first case report of lobomycosis was done in 1931 by the Brazilian dermatologist Jorge Lobo. This report was about a 52-year-old man who lived in the Amazon region and who presented with sacral lesions resembling keloid. This “new’’ disease was named “blastomicose keloidiana” (keloid blastomycosis).1
What kind of disease does Lacazia loboi cause?
Lobomycosis is a fungal infection caused by Lacazia loboi. This disease affects primarily the subcutaneous tissue manifested by a chronic granulomatous reaction, full of parasites, in the dermis. Keloid-like lesions are the most common clinical presentation. 1 – 3