What is CSF GM?
A substance that helps make more white blood cells, especially granulocytes, macrophages, and cells that become platelets. It is a cytokine that is a type of hematopoietic (blood-forming) agent. Also called granulocyte-macrophage colony-stimulating factor and sargramostim.
What is recombinant GM-CSF?
Recombinant human GM-CSF (rhGM-CSF) promotes the production of myeloid cells of the granulocytic (neutrophils, eosinophils and basophils) and monocytic lineages in vivo. It has been tested for mobilization of hematopoietic progenitor cells and for treating chemotherapy-induced neutropenia in patients.
What is G-CSF injection?
G-CSF injections are a synthetic version of this naturally occurring growth factor. G-CSF injections are given before you donate your stem cells to boost your white cells and to release stem cells into the bloodstream ready to collect. G-CSF is also given to some patients receiving treatment for cancer.
What is the purpose of G-CSF?
G-CSF helps the bone marrow make more white blood cells. It is a type of colony-stimulating factor. Also called filgrastim and granulocyte colony-stimulating factor.
What is GM-CSF cytokine?
GM-CSF is a monomeric glycoprotein that functions as a cytokine — it is a white blood cell growth factor. GM-CSF stimulates stem cells to produce granulocytes (neutrophils, eosinophils, and basophils) and monocytes.
What causes GM-CSF?
GM-CSF is produced by various cell types including macrophages, mast cells, T cells, fibroblasts and endothelial cells 8, 9, mostly in response to immune activation and cytokines that mediate inflammation.
How is GM-CSF administered?
The GM-CSF was administered subcutaneously in 28-day cycles, such that a dose of 125 microg/m2 was delivered daily for 14 days followed by 14 days rest. Treatment cycles continued for 3 years or until disease recurrence, which could not be surgically excised.
Is GM-CSF a cytokine?
Multiple studies have demonstrated that GM-CSF is also an immune-modulatory cytokine, capable of affecting not only the phenotype of myeloid lineage cells, but also T-cell activation through various myeloid intermediaries.
Does G-CSF increased platelets?
Primarily, G-CSF stimulates the bone marrow to produce granulocytes and stem cells. A decreased platelet count was occasionally observed after G-CSF injection. A previous study indicated that G-CSF also increases platelet turnover and loss.
Who makes GM-CSF?
GM-CSF is produced by multiple cell types such as activated T cells, B cells, macrophages, monocytes, mast cells, vascular endothelial cells, and fibroblasts (2).
What is the function of GM CSF in white blood cells?
GM-CSF is a monomeric glycoprotein that functions as a cytokine — it is a white blood cell growth factor. GM-CSF stimulates stem cells to produce granulocytes ( neutrophils, eosinophils, and basophils) and monocytes. Monocytes exit the circulation and migrate into tissue, whereupon they mature into macrophages and dendritic cells.
Is the GM-CSF receptor lineage specific or lineage specific?
In contrast to M-CSF and G-CSF which are lineage specific, GM-CSF and its receptor play a role in earlier stages of development.
How does GM-CSF differ from granulocyte colony stimulating factor?
Unlike granulocyte colony-stimulating factor, which specifically promotes neutrophil proliferation and maturation, GM-CSF affects more cell types, especially macrophages and eosinophils. GM-CSF is a monomeric glycoprotein that functions as a cytokine — it is a white blood cell growth factor.
What are the pharmaceutical analogs of GM-CSF?
The pharmaceutical analogs of naturally occurring GM-CSF are called sargramostim and molgramostim . Unlike granulocyte colony-stimulating factor, which specifically promotes neutrophil proliferation and maturation, GM-CSF affects more cell types, especially macrophages and eosinophils.