What is BFM chemotherapy?
During Induction, you will receive augmented Berlin-Frankfurt-Munster chemotherapy, which is made up of a combination of Cerubidine®, Daunorubicin Hydrochloride (daunorubicin), Oncovin® (vincristine), prednisone, dexamethasone, Oncaspar® (PEG Asparaginase), and MTX amethopterin (methotrexate).
What is Berlin Frankfurt Munster protocol?
The German Berlin, Frankfurt, Muenster (BFM) protocols have demonstrated excellent results in patients with ALL or lymphoblastic lymphoma. (See Table 2, below.) Unlike the LSA2 L2 protocol, the BFM regimen has a reinduction phase. It also features a less complicated and less intense maintenance phase.
What is aBFM regimen?
The aBFM regimen includes a second interim maintenance phase and intensification phase, as well as additional vincristine and L-asparaginase during the consolidation and reconsolidation phases.
What is Capizzi style methotrexate?
The methotrexate is given every 10 days. This is called “Capizzi I methotrexate” and was a component of previous trials, CCG 1961 (arms C/D) and POG 9906, during interim maintenance.
What Calgb 10403?
CALGB 10403 was the largest prospective study to evaluate the feasibility of using a pediatric regimen in AYAs with acute lymphoblastic leukemia up to 40 years of age.
How does L asparaginase work?
Asparaginase is an enzyme that breaks down asparagine. Unlike normal cells, ALL cells are unable to make their own asparagine. So asparaginase stops the cancer cells from dividing and growing.
How many rounds of chemo is needed for leukemia?
Most people have 2 rounds of induction chemotherapy. The treatment will be carried out in hospital or in a specialist centre, as you’ll need very close medical and nursing supervision. You may be able to go home between treatment rounds.
How long is a round of chemo for leukemia?
Chemo treatment for ALL is typically divided into 3 phases: Induction, which is short and intensive, usually lasts about a month. Consolidation (intensification), which is also intensive, typically lasts for a few months. Maintenance (post-consolidation), which is less intensive, typically lasts for about 2 years.
What are 2 primary uses for asparaginase?
Asparaginase is an enzyme that is used as a medication and in food manufacturing. As a medication, L-asparaginase is used to treat acute lymphoblastic leukemia (ALL). It is given by injection into a vein, muscle, or under the skin….Asparaginase.
| Clinical data | |
|---|---|
| IUPHAR/BPS | 7347 |
| DrugBank | DB00023 |
| ChemSpider | none |
| UNII | G4FQ3CKY5R |
What is the treatment for acute lymphoblastic leukemia?
Treatment Protocol for Children and Adolescents With Acute Lymphoblastic Leukemia – AIEOP-BFM ALL 2017 Condition or disease Intervention/treatment Phase Acute Lymphoblastic Leukemia, Pediatric Drug: Blinatumomab Drug: Bortezomib Drug Phase 3
What happens after a bone marrow biopsy with BFM?
After completing induction chemotherapy with the BFM regimen, patients underwent a bone marrow biopsy to confirm remission followed by ongoing treatment with either augmented or standard BFM chemotherapy based on their age and risk category.
What is the aieop-BFM all 2017 study?
The AIEOP-BFM ALL 2017 study therefore aims for an innovative integrated approach that will not only adapt the risk stratification to new prognostic markers using more comprehensive diagnostics, but above all, qualitatively reorient the therapy.