What is trophoblastic neoplasm?
Oncology. Gestational trophoblastic neoplasia (GTN) is group of rare diseases related to pregnancy and included in gestational trophoblastic disease (GTD) in which abnormal trophoblast cells grow in the uterus. GTN can be classified into benign and malignant lesions.
What does trophoblastic mean?
Listen to pronunciation. (TROH-foh-BLAST) A thin layer of cells that helps a developing embryo attach to the wall of the uterus, protects the embryo, and forms a part of the placenta.
What it is known as gestational trophoblastic neoplasia?
Recurrent gestational trophoblastic neoplasia (GTN) is cancer that has recurred (come back) after it has been treated. The cancer may come back in the uterus or in other parts of the body. Gestational trophoblastic neoplasia that does not respond to treatment is called resistant GTN.
What causes trophoblastic disease?
The most common types of gestational trophoblastic disease occur when a sperm cell fertilizes an empty egg cell or when two sperm cells fertilize a normal egg cell. Your risk is higher based on your: Age: Gestational trophoblastic disease occurs in women of childbearing age.
What happens to trophoblast after implantation?
In humans, implantation of a fertilized ovum occurs between 6 to 12 days after ovulation. In preparation for implantation, the blastocyst sheds its outside layer, the zona pellucida, and is replaced by a layer of underlying cells called the trophoblast. The trophoblast will give rise to the placenta after implantation.
Is GTD treatable?
GTD is typically curable, especially when found early. The main treatments for GTD are surgery and/or chemotherapy. Descriptions of the common types of treatments used for GTD are listed below. Your care plan may include treatment for symptoms and side effects, an important part of medical care.
How is trophoblastic disease diagnosed?
A hormone called human chorionic gonadotrophin (hCG) can help to diagnose persistent trophoblastic disease or choriocarcinoma. These tumours are types of gestational trophoblastic disease (GTD).
What kind of disease is gestational trophoblastic neoplasia?
Gestational trophoblastic neoplasia (GTN) is a type of gestational trophoblastic disease (GTD) that is almost always malignant.
Where does a placental-site trophoblastic tumor ( pstt ) form?
Placental-site trophoblastic tumors. A placental-site trophoblastic tumor (PSTT) is a rare type of gestational trophoblastic neoplasia that forms where the placenta attaches to the uterus. The tumor forms from trophoblast cells and spreads into the muscle of the uterus and into blood vessels.
Is there a cure for gestational trophoblastic disease?
Gestational trophoblastic disease usually can be cured. Treatment and prognosis depend on the following: The type of GTD. Whether the tumor has spread to the uterus, lymph nodes, or distant parts of the body. The number of tumors and where they are in the body. The size of the largest tumor.
What is the treatment for a recurrent trophoblastic tumor?
Treatment of recurrent or resistant gestational trophoblastic tumor may include the following: Chemotherapy with one or more anticancer drugs for tumors previously treated with surgery. Combination chemotherapy for tumors previously treated with chemotherapy. Surgery for tumors that do not respond to chemotherapy.