Can Prilosec cause iron deficiency anemia?

Can Prilosec cause iron deficiency anemia?

Omeprazole is known to cause prolonged suppression of gastric acid secretion. Since acid plays an important role in the absorption of food iron (nonheme iron), this drug may lead to an iron deficiency state.

Can omeprazole stop you absorbing iron?

If you are iron-deficient or have anemia, you should talk to your doctor before using ferrous sulfate together with omeprazole. By reducing stomach acid, omeprazole may reduce the absorption of iron and make ferrous sulfate less effective in treating your condition.

What medications block iron absorption?

Iron decreases the absorption of the following medications:

• Tetracyclines: Antibiotics that include doxycycline (Vibramycin), minocycline (Minocin), and tetracycline.
• Quinolones: Antibiotics that include ciprofloxacin (Cipro), norfloxacin (Noroxin), and levofloxacin (Levaquin).

Do proton pump inhibitors decrease iron absorption?

Taken together, PPIs directly affect iron metabolism by suppressing iron absorption through the inhibition of duodenal ferroportin via hepcidin upregulation. These findings provide a new insight into the molecular mechanism of PPI-induced iron deficiency.

Does omeprazole cause low ferritin?

Some studies suggest that prolonged omeprazole use for at least 3 to 4 years is unlikely to cause iron and ferritin malabsorption,6 whereas Sarzynski et al9 found that among adults on long-term PPI therapy, defined as >1 year, there was a significant decrease in hematologic indices from baseline.

Do antacids cause iron deficiency?

Additionally, the antacid calcium carbonate can inhibit iron absorption. However, there is little direct clinical evidence that proton-pump inhibitors, histamine-2 receptor antagonists, or calcium carbonate cause iron deficiency anemia.

What are the long-term side effects from taking omeprazole?

Despite their ease of availability and common use, PPIs can have severe side effects. The long-term consequences of chronic PPI use include the potential increased risk of hypocalcemia, hypomagnesemia, Clostridium difficile infections, and pneumonia.

Why is my body not absorbing iron?

Your body can’t absorb iron. Conditions like celiac disease, ulcerative colitis, or Crohn’s disease can make it harder for your intestines to absorb iron. Surgery such as gastric bypass that removes part of your intestines, and medicines used to lower stomach acid can also affect your body’s ability to absorb iron.

Do Tums affect iron absorption?

Antacids can interfere with the absorption of iron, zinc, and other minerals by neutralizing stomach acid. Research suggests that antacids physically bind to folate and reduce its absorption by the body. Antacids that contain calcium may also compete for absorption with iron and impair iron absorption.

Does PPI cause low iron?

Although the long-term use of PPIs is considered safe, there are several reported cases of iron deficiency anemia due to PPI use (2-4) and a community-based case control study reported that the risk of iron deficiency was increased among long-term PPI users (5).

Which antacids interfere with iron absorption?

Iron deficiency anemia is often listed among potential adverse effects of gastric acid-suppressive medications, given that gastric acidity promotes intestinal absorption of nonheme iron. Additionally, the antacid calcium carbonate can inhibit iron absorption.

Do antacids affect iron levels?

Liquid antacid containing aluminum hydroxide and magnesium hydroxide did not significantly decrease iron absorption. Sodium bicarbonate and calcium carbonate caused the plasma iron increase to be 50% and 67% less than the control values, respectively.