Is Hexamethylphosphoramide an aprotic solvent?
An Aprotic Solvent for Active Metals.
How do you quench Hmpa?
You may use brine (saturated sodium chloride solution) to break the emulsions formed. If you use dichloromethane, simply extract the solution twice with equal volume water. If you product is stable to acid, I would highly recommend washing your extract with 0.5 M HCl.
Is Hmpa soluble in water?
Hexamethylphosphoramide
| Names | |
|---|---|
| Melting point | 7.20 °C (44.96 °F; 280.35 K) |
| Boiling point | 232.5 °C (450.5 °F; 505.6 K) CRC |
| Solubility in water | miscible |
| Vapor pressure | 0.03 mmHg (4.0 Pa) at 20 °C |
What is the structure of Hmpa?
Tetrahydrofuran HMPA
| PubChem CID | 86583969 |
|---|---|
| Structure | Find Similar Structures |
| Molecular Formula | C10H26N3O2P |
| Synonyms | tetrahydrofuran HMPA HMPA THF THF HMPA THF HMPT SCHEMBL2646439 More… |
| Molecular Weight | 251.31 |
Is HMPA polar aprotic?
Hexamethylphosphoric acid triamide (HMPA) is known to be an excellent polar aprotic solvent (ET = 40.9).
Why is HMPA toxic?
HMPA should be regarded as a substance with poor warning properties. Combustible liquid. Its decomposition at high temperatures or in a fire can produce phosphine, phosphorus oxides, and oxides of nitrogen, which are extremely toxic.
Is HMPA polar?
Why is Hmpa toxic?
Is h2o Protic?
Water is the most common protic solvent. Conversely, polar aprotic solvents cannot donate protons but still have the ability to dissolve many salts.
Is Hmpa polar aprotic?
Is DMF polar?
DMF is a polar (hydrophilic) aprotic solvent with a high boiling point. It facilitates reactions that follow polar mechanisms, such as SN2 reactions.
Is HMPA Protic or aprotic?
What is the formula for hexamethylphosphoramide ( HMPA )?
Hexamethylphosphoramide, often abbreviated HMPA, is a phosphoramide (an amide of phosphoric acid) with the formula [ (CH3)2N]3PO. This colorless liquid is a useful reagent in organic synthesis .
Is it safe to use hexamethylphosphoramide in humans?
Hexamethylphosphoramide is a clear colorless to light amber liquid with a spicy odor. (NTP, 1992) Hexamethylphosphoramide is no longer used in large quantities in the United States. No information is available on the acute (short-term), chronic (long-term), reproductive, developmental, or carcinogenic effects of hexamethylphosphoramide in humans.
What kind of odor does hexamethylphosphoramide have?
Computed by OEChem 2.3.0 (PubChem release 2021.05.07) Hexamethylphosphoramide is a clear colorless to light amber liquid with a spicy odor. (NTP, 1992) National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992.
What happens to hexamethylphosphoramide in the atmosphere?
In water, hexamethylphosphoramide is not expected to bioconcentrate in aquatic organisms or volatilize from aquatic systems. If released to the atmosphere, hexamethylphosphoramide is expected to exist almost entirely in the vapor phase in the ambient atmosphere.