What causes febrile neutropenia?
Causes. Febrile neutropenia can develop in any form of neutropenia, but is most generally recognized as a complication of chemotherapy when it is myelosuppressive (suppresses the bone marrow from producing blood cells).
What causes transient neutropenia?
The non-infectious causes which cause transient neutropenia are further divided into inflammatory and autoimmune disease, as well as drug-induced. Most common viral agents include the Epstein-Barr virus, human immunodeficiency virus (HIV), influenza, parvovirus B19, and cytomegalovirus.
Does carbamazepine cause neutropenia?
Transient leukopenia and, less commonly, neutropenia may occur with carbamazepine therapy. Discontinuation of therapy is usually not indicated unless symptoms are severe, persistent, or accompanied by infection.
Can cipro cause neutropenia?
Drug‐induced neutropenia is the second most common cause, and postmarketing of ciprofloxacin has reported agranulocytosis in 0.4% of patients. There have only been 3 published case reports in the English language of this adverse reaction.
How do you treat febrile neutropenia?
Recommended treatment for low-risk patients includes combination oral antibiotic therapy with ciprofloxacin and amoxicillin-clavulanate. Other orally administered regimens commonly used in clinical practice are monotherapy with levofloxacin or ciprofloxacin and combination with ciprofloxacin and clindamycin.
What does febrile neutropenia mean?
Listen to pronunciation. (FEH-brile noo-troh-PEE-nee-uh) A condition marked by fever and a lower-than-normal number of neutrophils in the blood. A neutrophil is a type of white blood cell that helps fight infection.
Is neutropenia an autoimmune disease?
Neutropenia associated with immunodeficiency. Neutropenia can be associated with a deficit of both innate and acquired immunity but in most cases the mechanism is not autoimmune.
How long does transient neutropenia last?
Neutropenia that occurs with common childhood viral diseases develops during the first 1 to 2 days of illness and may persist for 3 to 8 days. Transient neutropenia may also result from virus- or endotoxemia-induced redistribution of neutrophils from the circulating to the marginal pool.
Can medications cause neutropenia?
There are many medications that can result in drug-induced neutropenia. The most common are carbimazole, clozapine, dapsone, dipyrone, methimazole, penicillin G, procainamide, propylthiouracil, rituximab, sulfasalazine, and ticlopidine.
Can carbamazepine cause low white blood cells?
Carbamazepine may cause rare but serious blood problems including low white blood cell counts. Symptoms may include: fever, sore throat, or other infections that come and go or do not go away, easy bruising, red or purple spots on your body, bleeding gums or nose bleeds, or severe fatigue or weakness.
Can Cipro lower WBC?
Ciprofloxacin Tablets are used for the treatment of severe bacterial infections. They only work with specific strains of bacteria. Ciprofloxacin may be used in the management of patients with low white blood cell counts (neutropenia) who have a fever that is suspected to be due to a bacterial infection.
Which antibiotics cause neutropenia?
The drugs most commonly associated with neutropenia are antibiotics (particularly beta-lactam and trimethoprim-sulfamethoxasole) as well as antithyroid drugs, antiplatelet agents, nonsteroidal anti-inflammatory agents, and noramidopyrin (3).
What do you need to know about neutropenia in adults?
Neutropenia (noo-troe-PEE-nee-uh) is an abnormally low level of neutrophils. Neutrophils are a common type of white blood cell important to fighting off infections — particularly those caused by bacteria. For adults, counts of less than 1,500 neutrophils per microliter of blood are considered to be neutropenia.
What kind of white blood cell is neutropenia?
Neutrophils are a common type of white blood cell important to fighting off infections — particularly those caused by bacteria. For adults, counts of less than 1,500 neutrophils per microliter of blood are considered to be neutropenia. For children, the cell count indicating neutropenia varies with age.
Can you get neutropenia if you have cancer?
Neutropenia can happen to anyone. It sometimes results from an infection, but it is also often a result of treatment for cancer. It is estimated that 50 percent of the people who get chemotherapy will develop neutropenia. Some ethnic groups may have neutrophil counts in the 1,200 range that are considered normal for them.
What to do if you have febrile neutropenia?
Your doctor will prescribe drugs to fight the infection, such as antibiotics. If you do develop febrile neutropenia, your doctor is likely to admit you to the hospital. You may get your antibiotics intravenously (through a vein).