What is the function of nicorandil?
Nicorandil is a type of medicine called a potassium-channel activator. It works by relaxing and widening your blood vessels, which increases the supply of blood and oxygen to your heart. This helps reduce the chest pain angina causes.
Is nicorandil a vasodilator?
Nicorandil is a balanced vasodilator that acts as both NO donor and arterial K(+) ATP channel opener. Nicorandil might also exhibit cardioprotective properties via mitochondrial ischemic preconditioning.
What class of drug is nicorandil?
Nicorandil belongs to the class of compounds known as potassium channel activators which are characterised by their arterial vasodilator properties. In addition, nicorandil has venodilating properties which are attributable to a nitrate group in its chemical structure.
Is nicorandil a calcium channel blockers?
Nicorandil exerts an antianginal effect by increasing coronary blood flow, preventing coronary artery spasms, and causing arterial vasodilatation. Therefore, as with nitrates and dihydro- pyridine calcium-channel blockers, nicorandil improves the balance of oxygen demand and delivery.
What is trimetazidine 35mg?
Trimetazidine is an anti-ischemic metabolic modulator [120], with similar anti-anginal efficacy to propranolol in doses of 20mg thrice daily. From: Coronary Artery Disease, 2018.
What is the mechanism of action of diltiazem?
Mechanism of Action Primarily, diltiazem inhibits the inflow of calcium ions into the cardiac, smooth muscle during depolarization. Reduced intracellular calcium concentrations equate to increased smooth muscle relaxation resulting in arterial vasodilation and, therefore, decreased blood pressure.
How does nicorandil cause vasodilation?
Nicorandil is a drug with a dual action. It generates nitric oxide, and it also opens potassium channels in the sarcolemma (ATP-dependent potassium channel). The latter action causes the smooth muscle cell to hyperpolarize and relax, leading to vasodilation of blood vessels.
What is Concor 5mg used for?
Concor 5mg Tablet 10’s is an antihypertensive drug that is used in the treatment of hypertension (high blood pressure), angina pectoris (chest pain with painful tightness in the chest), arrhythmias (irregular heartbeats). It protects the heart in the early treatment after myocardial infarction (heart attack).
How do you take nicorandil?
You can take nicorandil tablets either before or after meals. Swallow the tablet with a drink of water. If you forget to take a dose, take it as soon as you remember (unless it is nearly time for your next dose, in which case leave out the missed dose). Do not take two doses together to make up for a forgotten dose.
Can you take nicorandil and amlodipine together?
Amlodipine. Both nicorandil and amlodipine can increase the risk of hypotension.
What is the mechanism of action of atorvastatin?
Mechanism of Action Atorvastatin competitively inhibits 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. [2] By preventing the conversion of HMG-CoA to mevalonate, statin medications decrease cholesterol production in the liver.
What are the two main mechanisms of action of nicorandil?
Nicorandil mediates its therapeutic efficacy via two main mechanisms. Nicorandil is an activator and opener of ATP-sensitive (ATP-dependent) potassium channels (KATP channels) that are composed of Kir6.x-type subunits and sulfonylurea receptor (SUR) subunits.
What does nicorandil do to the smooth muscle?
Nicorandil is a dual-action potassium channel opener that relaxes vascular smooth muscle through membrane hyperpolarization via increased transmembrane potassium conductance and increased intracellular concentration of cyclic GMP. It is shown to dilate normal and stenotic coronary arteries and reduces both ventricular preload and afterload.
How long is the elimination half life of nicorandil?
The elimination half life is approximately 1 hour [ A20328 ]. Nicorandil mediates its therapeutic efficacy via two main mechanisms. Nicorandil is an activator and opener of ATP -sensitive ( ATP -dependent) potassium channels (KATP channels) that are composed of Kir6.x-type subunits and sulfonylurea receptor (SUR) subunits.
How does atp-nbd1 interaction affect nicorandil?
ATP-NBD1 interaction influences the channel signalling by nicorandil, and the response of the channel to nicorandil is also facilitated and heightened by the interaction of ATP or ADP with NBD2 3.