What are the symptoms of polymicrogyria?
Bilateral forms of polymicrogyria tend to cause more severe neurological problems. Signs and symptoms of these conditions can include recurrent seizures (epilepsy), delayed development, crossed eyes, problems with speech and swallowing, and muscle weakness or paralysis.
What is bilateral frontoparietal?
Overview. Bilateral frontoparietal polymicrogyria (BFPP) is a rare neurological disorder that affects the cerebral cortex (the outer surface of the brain). BFPP specifically affects the frontal and parietal lobes on both sides of the brain (bilateral).
Does polymicrogyria affect life expectancy?
The quality of life and life expectancy for people with BPP are not well-described but may depend on severity of symptoms, whether complications develop, and whether other birth defects or an underlying syndrome are present.
What causes bilateral Perisylvian polymicrogyria?
Genetic causes may include a contiguous gene disorder (a disorder caused by the deletion of multiple adjacent genes ) or a single gene disorder (a disorder caused by a mutation in one gene). BPP may also have non-genetic causes.
What is bilateral Polymicrogyria?
Bilateral perisylvian polymicrogyria (BPP) is a rare neurological disorder that affects the cerebral cortex (the outer surface of the brain). BPP is a subtype of a broader condition known as polymicrogyria. The cerebral cortex of the brain normally consists of several deep folds and grooves.
What are treatments for Polymicrogyria?
The Polymicrogyria (PMG) malformation cannot be reversed, but the symptoms may be treated in children and adults. The first-line treatment for persons with seizures is anti-seizure medications, and the medication chosen depends on the type of seizures or epilepsy syndrome.
What causes Polymicrogyria?
There are several known causes for polymicrogyria. The most common of which results from the virus cytomegalovirus (CMV). Other causes include various prenatal infections, brain abnormalities, genetic disorders, and more. This condition may also result from brain injury while a baby is still in the womb.
Is PMG hereditary?
Other causes can be environmental, a problem with oxygen to the fetus, or genetic anomalies. There are rare instances of some hereditary forms of PMG. Much more needs to be researched but the funding for research is very poor.
What does Perisylvian mean?
the area of the brain that is responsible for language. It consists of the region around the lateral sulcus (Sylvian fissure) of the left hemisphere and includes Broca’s area and Wernicke’s area. Damage to the zone causes various forms of aphasia.
What is bilateral syndrome?
Congenital bilateral perisylvian syndrome (CBPS) is a rare neurological disease characterized by paralysis of certain facial muscles and epileptic seizures.
What is the life expectancy of a child with lissencephaly?
Children with severe lissencephaly have a life expectancy of about 10 years, according to the National Institute of Neurological Disorders and Stroke .
How common is Megalencephaly?
Megalencephaly is three to four time more common in males than females, reports The Gale Encyclopedia of Neurological Disorders. It affects between 10 and 30 percent of patients with macrocephaly. Asymptomatic cases may not be reported, so the incidence is unknown.
What are the symptoms of bilateral frontoparietal polymicrogyria?
The signs and symptoms of bilateral frontoparietal polymicrogyria vary but may include: Moderate to severe intellectual disability. Developmental delay. Seizures. Dysconjugate gaze (eyes that are not aligned) Ataxia. Strabismus. Increased muscle tone.
How does polymicrogyria affect the frontal and parietal lobes?
Bilateral frontoparietal polymicrogyria specifically affects the frontal and parietal lobes on both sides of the brain (bilateral). MRI in bilateral frontoparietal polymicrogyria patients shows bilateral white matter abnormalities and atrophy of the brain stem and cerebellum (Figure 2) 23).
What kind of brain disorder is bilateral polymicrogyria?
Bilateral frontoparietal polymicrogyria is a rare neurological disorder that affects the cerebral cortex (the outer surface of the brain). Bilateral frontoparietal polymicrogyria specifically affects the frontal and parietal lobes on both sides of the brain (bilateral).
Which is the most severe form of polymicrogyria?
In the most severe forms, polymicrogyria is bilateral and generalized, resulting in severe intellectual disability, cerebral palsy, and refractory epilepsy.