Does busulfan cause pulmonary fibrosis?

Does busulfan cause pulmonary fibrosis?

An uncommon, but lethal, toxic side effect of busulfan (Myleran) therapy for chronic myelogenous leukemia is pulmonary fibrosis. A 16-month-old male infant treated for 11 months with busulfan for chronic myelogenous leukemia is, we believe, the first case of “busulfan lung” in the pediatric age group to be reported.

What is busulfan toxicity?

Busulfan was the first cytotoxic drug reportedly associated with pulmonary toxicity [1]. The reported patterns of pulmonary toxicity include acute lung injury, chronic interstitial fibrosis, and alveolar hemorrhage.

What are the symptoms of pulmonary toxicity?

What are the symptoms of lung toxicity?

• Breathlessness during exercise.
• Fatigue.
• Dry cough.
• Shortness of breath.
• Discomfort or worsening symptoms when lying on your back.

What is busulfan lung damage?

Busulfan can cause interstitial fibrosing lung disease (“busulfan lung”) with an estimated incidence of 6% [5]. It begins gradually, causes dyspnea and cough, and is often accompanied by skin pigmentation. It usually occurs after prolonged treatment (on average 41 months, cumulative dose 2900 mg).

What is bleomycin lung injury?

The lung injury seen following bleomycin comprises an interstitial oedema with an influx of inflammatory and immune cells. This may lead to the development of pulmonary fibrosis, characterized by enhanced production and deposition of collagen and other matrix components.

Is busulfan carcinogenic?

Busulfan is a direct-acting alkylating agent that is carcinogenic via a genotoxic mechanism.

Can you reverse lung damage?

While there’s no way to reverse scarring or lung damage that years of smoking can cause, there are things you can do to prevent further damage and improve your lung health.

How much does busulfan cost?

The cost for Busulfex intravenous solution (6 mg/mL) is around $4,186 for a supply of 80 milliliters, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.

Does busulfan cause secondary leukemia?

Seizures may occur with high doses used in bone marrow transplant. Anti-seizure medications are often used to prevent this. Increased risk of secondary cancer such as acute leukemia especially with long-term use of the drug.

Does busulfan cause encephalitis?

Busulfan might cause encephalopathy by an indirect mechanism. The drug has been implicated in a higher incidence of hepatic veno-occlusive disease and centrilobular hepatic degeneration following bone marrow transplantation compared to nonbusulfan-containing regimens.

Are there any side effects to Taking busulfan?

Some side effects of busulfan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

What kind of drug is busulfan for cancer?

Drug type: Busulfan is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. This medication is classified as an “alkylating agent.”

How is busulfan taken in the United States?

Busulfan is taken by mouth in pill form. It also may be given as an infusion into the vein (intravenous or IV). The amount of busulfan that you will receive and how it is given depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer or condition being treated.