What is the function of the protein uromodulin?
The function of uromodulin remains unclear, although it is known to be the most abundant protein in the urine of healthy individuals. Researchers have suggested that uromodulin may protect against urinary tract infections. It may also help control the amount of water in urine.
How is uromodulin related to type 1 diabetes?
Serum uromodulin is associated with urinary albumin excretion in adolescents with type 1 diabetes. Serum uromodulin is inversely associated with arterial hypertension and the vasoconstrictive prohormone CT-proET-1 in the population-based KORA F4 study.
How is uromodulin similar to a mouse oligomer?
Uromodulin forms high molecular weight oligomers that line the kidney tubules. Human Uromodulin is GPI-linked. Human Uromodulin is 78% aa identical to mouse Uromodulin. ” Uromodulin ” has 8 results in Products.
What are the domains in the uromodulin matrix?
It is the matrix of urinary casts derived from the secretion of renal tubular cells. Uromodulin consists of an N-terminal EGF domain, two calcium-binding EGF domains, a cysteine -rich domain (D8C), a fourth EGF domain and a C-terminal Zona pellucida-like (ZP) domain.
The function of uromodulin remains elusive, but the available data suggest that this protein might regulate salt transport, protect against urinary tract infection and kidney stones, and have roles in kidney injury and innate immunity.
What causes Uromodulin-associated kidney disease ( UMOD )?
It accounts for fewer than 1 percent of cases of kidney disease. Mutations in the UMOD gene cause uromodulin-associated kidney disease. This gene provides instructions for making the uromodulin protein, which is produced by the kidneys and then excreted from the body in urine.
What is the role of uromodulin in renal stone formation?
Uromodulin modulates cell adhesion and signal transduction by interacting with cytokines and it inhibits the aggregation of calcium crystals. By reducing calcium oxalate precipitation, uromodulin plays a protective role with respect to renal stone formation as demonstrated by recent studies on THP- deficient mice prone to nephrolithiasis.
When do you need a kidney transplant with uromodulin?
Individuals with uromodulin-associated kidney disease typically require either dialysis to remove wastes from the blood or a kidney transplant between the ages of 30 and 70. Occasionally, affected individuals are found to have small kidneys or kidney cysts (medullary cysts).