Does proton pump inhibitors cause dementia?
Recent clinical studies have shown that proton pump inhibitors (PPIs) are associated with risk of dementia, including AD. However, a recent case-control study reported decreased risk of dementia.
Which acid reducers cause dementia?
The most common PPIs in use were omeprazole (Prilosec), pantoprazole (Protonix), and esomeprazole (Nexium). All participants were free of dementia at the study’s beginning. Yet, after the eight-year follow-up, chronic PPI users had a 44% increased risk of dementia compared with those who did not take any medication.
Does esomeprazole cause dementia?
Three studies have found a positive association between dementia and omeprazole, esomeprazole, lansoprazole, and pantropazole, with an approximately 1.4-fold increased risk of any dementia in cohorts using PPIs (95% CI, 1.36–1.52; P < 0.001) [76].
Can proton pump inhibitors cause memory loss?
Memory impairment related ADRs found that PPIs users were at increased risk of dementia (Hazard Ratio (HR) 1.38, 95% CI, [1.04–1.83]) and AD (HR, 1.44, 95% CI, [1.01, 2.06]) compared to non-users19.
Why do PPIs cause dementia?
Some experimental18 and clinical19 studies in recent years have found that proton pump inhibitors (PPIs) are associated with an increased risk of dementia and AD. PPIs block the H+ and K+-ATPase and, as a result, suppress the secretion of gastric acid.
Does Protonix cause Alzheimer’s?
The patients who had been regularly taking a PPI, such as omeprazole (Prilosec), pantoprazole (Protonix), lansoprazole (Prevacid), esomeprazole (Nexium) and rabeprazole (AcipHex), had a significantly increased risk of incident dementia compared with patients who did not take the medication.
Is there an alternative to PPI medication?
Although PPIs were found to be more effective in treating symptoms and complications associated with GERD, H2 blockers have proven to be just as effective in suppressing gastric acid. H2 blockers are available by prescription or over-the-counter, and include ranitidine, famotidine, cimetidine and nizatidine.
Which is better PPI or H2 blocker?
Proton-pump inhibitors, or PPIs — such as omeprazole (Prilosec), lansoprazole (Prevacid), or esomeprazole (Nexium) — are stronger than H2 blockers. They inhibit certain cells from “pumping” acid into the stomach, which lowers acid levels and heartburn pain.
What can I use instead of a PPI?
Alternatives to PPIs
- Cimetidine (Tagamet)
- Ranitidine (Zantac)
- Nizatidine (Axid)
- Famotidine (Pepcid)
Do antacids cause dementia?
Study: Long term use of antacids could lead to increased risk for dementia. If you’re taking prescription heartburn pills, experts say you may want to be concerned. A recently published study shows that using antacids for a long duration may increase the risk of developing dementia.
Do antacids cause Alzheimer’s?
A very large meta-analysis of 9 observational studies including more than 6,000 people reported that regular antacid use was not associated with Alzheimer’s disease [18]. Even when the analysis was confined to people who used antacids regularly for over 6 months, there was no association with Alzheimer’s.
Does long-term use of PPI cause dementia?
Three large epidemiological studies—two in Germany and one in Taiwan- showed that long-term exposure to PPIs increases the risk of developing dementia in the elderly19,23,24.
Is there a link between PPI and dementia?
Most studies included patients who had been undergoing treatment with PPIs for 5 to 10 years. Ten studies were considered of high quality, while the remaining study was of moderate quality. The pooled hazard ratio (HR) for dementia was 1.10 (95% CI, 0.88-1.37). When Alzheimer dementia alone was evaluated, the HR was 1.06 (95% CI, 0.72-1.55).
Are there any proton pump inhibitors that cause dementia?
Proton Pump Inhibitors Linked to Dementia. The new study, by Willy Gomm, PhD, from the German Center for Neurodegenerative Diseases, Bonn, Germany, and colleagues and published online February 15 in JAMA Neurology, is important, as PPIs are among the most frequently prescribed drugs and their use has been increasing sharply,…
How is polypharmacy related to the risk of dementia?
Having diabetes and being prescribed five or more drugs other than the PPI (defined as polypharmacy) were also associated with significantly elevated dementia risk. “In our analysis, polypharmacy elevated the risk for occurrence of dementia by about 16%,” commented Dr Haenisch.
Is there a link between anticholinergic drugs and dementia?
Here are some links: Anticholinergic Drugs and Dementia: The Link Gets Much Stronger! Alzheimer disease is devastating. People assume it is caused by bad genes or bad luck. There are increasing data linking anticholinergic drugs and dementia. Where Can I Find A List of Anticholinergic Drugs?