What are side effects of eplerenone?
Eplerenone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- headache.
- dizziness.
- diarrhea.
- stomach pain.
- cough.
- excessive tiredness.
- flu-like symptoms.
- breast enlargement or tenderness.
Why is eplerenone used?
About eplerenone It’s used to treat heart failure and reduce the risk of you having other heart problems or a stroke. It also helps to stop heart failure getting worse. It can sometimes be used to treat a condition called hyperaldosteronism.
What is the difference between spironolactone and eplerenone?
Pharmacological differences between spironolactone and eplerenone include lower affinity of eplerenone for progesterone, androgen, and glucocorticoid receptors; more consistently demonstrated nongenomic properties for eplerenone; and the presence of long-acting metabolites for spironolactone.
Is eplerenone a diuretic?
Eplerenone and spironolactone increase natriuresis and cause renal retention of potassium when plasma aldosterone is high, i.e., both agents are facultative diuretics. Eplerenone reduces high blood pressure effectively.
Can eplerenone cause heart failure?
Eplerenone works by interfering with the activity of a steroid in your body called aldosterone. Aldosterone acts to increase the amount of sodium and water you retain. This increased sodium and water can cause high blood pressure, which can in turn cause heart failure.
Does eplerenone affect heart rate?
There was no effect of eplerenone on heart rate. At the lower doses of 50 mg and 100 mg/d, twice-daily dosing (ie, 25 mg bid and 50 mg bid) reduced seated systolic and diastolic blood pressures to a greater extent than did once-daily dosing. Eplerenone also significantly decreased ambulatory blood pressure.
Does eplerenone cause a cough?
The more common side effects that can occur with eplerenone include: dizziness. diarrhea. coughing.
Can you take eplerenone and furosemide together?
No interactions were found between eplerenone and Lasix. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
What is the advantage of eplerenone over spironolactone?
A major advantage of eplerenone over the nonselective aldosterone receptor antagonist spironolactone is lack of binding to progesterone and androgen receptors, which is associated with drug-induced gynecomastia, breast pain, and impotence.
When is eplerenone preferred over spironolactone?
Concerning its use in hypertension, eplerenone is not a recommended agent for the initial treatment of hypertension. However, eplerenone and spironolactone are preferred agents for patients with hypertension due to primary aldosteronism or resistant hypertension.
Can eplerenone cause shortness of breath?
Eplerenone can cause a severe allergic reaction. Symptoms include: trouble breathing. swelling of your throat or tongue.