What are Chalcone derivatives?
Chalcones are one of the major classes of naturally occurring compounds. Chalcones and their derivatives have a huge importance in medicinal chemistry, displaying a wide range of pharmacological activities including anti-inflammatory, antimicrobial, antioxidant, cytotoxic and antitumor actions.
Which drug is benzimidazole derivative?
Benzimidazole Derivatives
| Drug | Drug Description |
|---|---|
| Albendazole | A benzimidazole anthelmintic used to treat parenchymal neurocysticercosis and other helminth infections. |
| Mebendazole | A benzimidazole anthelmintic used to treat helminth infections. |
What is Chalcone synthesis?
Chalcone is synthesized by Claisen-Schmidt condensation, which involves the cross-aldol condensation of aldehydes and ketones with a base or acid catalyst followed by a dehydration reaction. Chalcone is a common natural pigment and one of the important intermediaries in flavonoid biosynthesis [2].
What is the use of Chalcone?
Currently, chalcone derivatives have been widely used for the treatment of viral disorders, cardiovascular diseases, stomach cancer, food additives, and cosmetic formulation ingredients [5].
What is a Chalcone in chemistry?
Studies in Natural Products Chemistry Chalcones are a group of plant-derived polyphenolic compounds belonging to the flavonoids family. Chalcones, aromatic ketones and enones, are known for their anticancer effects.
How do you synthesize Chalcones?
Synthesis. Chalcones can be prepared by an aldol condensation between benzaldehyde and acetophenone in the presence of sodium hydroxide as a catalyst. This reaction can be carried out without any solvent as a solid-state reaction.
Is mebendazole a benzimidazole?
The benzimidazoles (albendazole, mebendazole) are the only drugs available for drug treatment of CE.
What is Chalcone found in?
Indeed, chalcones constitute an important group of natural compounds that are especially abundant in fruits (e.g., citruses, apples), vegetables (e.g., tomatoes, shallots, bean sprouts, potatoes) and various plants and spices (e.g., licorice),—many of which have been used for centuries in traditional herbal medicine [ …
What is meant by Chalcone?
: a yellow crystalline ketone C6H5CHCHCOC6H5 made by the condensation of benzaldehyde and acetophenone also : any of various derivatives of this compound, several of which are plant pigments related to the flavones.
Which is the name of the parent compound of benzimidazole?
Although benzimidazole is the commonest name of the parent compound of the series, other names such as benzimidazole and 1,3-benzodiazole (1) are often used. Mono acyl derivative of o-phenylenediamine is readily converted into the corresponding benzimidazole by the action of heat alone.
What do you need to know about benzimidazoles?
The substituted benzimidazoles are summarized in this review to know about the chemistry as well as pharmacological activities. 1. Introduction Imidazole is the accepted name for the parent compound in the series, the numbering of which follows the accepted pattern for heterocyclic compound.
How is a mono acyl derivative converted to a benzimidazole?
Mono acyl derivative of o-phenylenediamine is readily converted into the corresponding benzimidazole by the action of heat alone. These conversions are generally carried out at a temperature somewhat above the melting point of the starting compounds.
How is a diamine converted to a benzimidazole?
In this method, the diamine is simply heated with excess acid ( Fischer, 1905 ).This procedure has been recommended as a means of identifying fatty acid α-hydroxy acid as well as phenylacetic acid and diphenylacetic acid are converted into the corresponding benzimidazoles when heated with o-phenylenediamine.