What is Proleukin used for?
Aldesleukin is used to treat kidney or skin cancer. This medication is the same as a substance that your body normally makes (interleukin-2). In the body, this drug is thought to work by affecting the body’s natural defenses (immune system).
What type of drug is Proleukin?
Proleukin is classified as a “biologic response modifier (BRM)” or “biologic therapy.” BRMs modify the body’s response to cancer cells.
Who manufactures Proleukin?
London-based Clinigen Group pc will have full rights to Proleukin (aldesleukin, human recombinant interleukin-2). This morning, the U.K.-based pharmaceutical and services company struck a deal with Novartis to acquire the U.S. rights to the metastatic renal cell carcinoma treatment.
How is aldesleukin made?
Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2.
Which condition is an absolute contraindications for administering Aldesleukin?
Re-treatment with aldesleukin is contraindicated with the following toxicities: Sustained ventricular tachycardia (≥5 beats), uncontrolled or unresponsive cardiac arrhythmias, chest pain with ECG changes consistent with angina or MI, cardiac tamponade, intubation >72 hours, renal failure requiring dialysis for >72 …
What is metastatic renal cell carcinoma?
Metastatic renal cell carcinoma is cancer in your kidneys that has spread to other parts of your body. It’s also called stage IV renal cell cancer. Cancer is harder to treat after it spreads, but it’s not impossible. You and your doctor still have many options.
Which route would the nurse administer Aldesleukin?
Aldesleukin has been approved for cancer treatment with a high-dose regimen, but it may also be administered in a low-dose form. The high-dose regimen involves giving the drug intravenously (into a vein) every 8 hours, as tolerated, for up to 14 doses.
Which condition is an absolute contraindication for administering Aldesleukin?
Is Aldesleukin a monoclonal antibody?
Monoclonal Antibody Ch14. 18, Sargramostim, Aldesleukin, and Isotretinoin After Autologous Stem Cell Transplant in Treating Patients With Neuroblastoma – Full Text View – ClinicalTrials.gov.
Does azathioprine cause immunosuppression?
As azathioprine is an immunosuppressant; this means your body’s resistance to infection can be reduced while you are taking azathioprine. You should avoid close contact with people who have infections. Azathioprine affects the way the body’s immune system works, which can make you more likely to catch infections.
Which adverse effect is associated with furosemide?
Too much furosemide can cause headaches, dizziness, a pounding or irregular heartbeat and fainting. You may also pee more than normal and feel thirsty. The amount of furosemide that can lead to an overdose varies from person to person.
How long can you live with metastatic renal cell carcinoma?
The 5-year survival rate for patients with RCC confined to the kidney is approximately 95%. However, metastases are known to occur in approximately 30% of cases, which confers a 5-year survival rate ranging from 0% to 20% for patients with metastatic disease.
What is aldesleukin and how does it work?
What is aldesleukin, and how does it work (mechanism of action)? Aldesleukin is a man-made protein that has the same action as native human interleukin-2 (IL-2) that is used for treating cancer of the kidney and skin. Interleukins are the messengers by which white blood cells communicate with each other to coordinate inflammation and immunity.
What kind of cancer is Proleukin used for?
Aldesleukin (Proleukin) is an interleukin injection drug prescribed to treat wide-spread cancer of the kidney and skin (melanoma).
How big is the molecular weight of Proleukin?
Reference ID: 3165255 DESCRIPTION Proleukin ® (aldesleukin), a human recombinant interleukin-2 product, is a highly purified protein with a molecular weight of approximately 15,300 daltons. The chemical name is des alanyl-1, serine-125 human interleukin-2.
Which is a recombinant analog of interleukin-2?
Aldesleukin is a recombinant analog of interleukin-2 used to induce an adaptive immune response in the treatment of renal cell carcinoma. Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene.