Does simvastatin cause more Myotoxicity compared with other statins?
Conclusions: Overall, the rates of severe myotoxicity with all statins are low, especially with low-to-moderate doses. However, recent trials for those using simvastatin 80 mg daily suggest a higher incidence of myotoxicity compared with maximum approved doses of other statins.
What is statin induced Myotoxicity?
Statin induced myotoxicity is a common adverse event and a major barrier to maximising cardiovascular risk reduction. • Statin induced myotoxicity may cause an asymptomatic rise in creatine kinase concentration, myalgia, myositis, rhabdomyolysis and necrotizing autoimmune myopathy.
What drug company makes simvastatin?
Merck
ZOCOR® (simvastatin) – Merck.com.
What drugs should not be taken with simvastatin?
Do not use more than 20 mg per day of simvastatin together with amiodarone (Cordarone®), amlodipine (Norvasc®), lomitapide (Juxtapid™), or ranolazine (Ranexa®). When used together with higher doses of simvastatin, these medicines may increase your risk of muscle injury and could result in kidney problems.
Which statin has the least amount of side effects?
In the analysis of 135 previous studies, which included nearly 250,000 people combined, researchers found that the drugs simvastatin (Zocor) and pravastatin (Pravachol) had the fewest side effects in this class of medications. They also found that lower doses produced fewer side effects in general.
Can statin cause liver damage?
Very rarely, statins can cause life-threatening muscle damage called rhabdomyolysis (rab-doe-my-OL-ih-sis). Rhabdomyolysis can cause severe muscle pain, liver damage, kidney failure and death. The risk of very serious side effects is extremely low, and calculated in a few cases per million people taking statins.
Does statin induced myopathy go away?
For most patients, myopathy symptoms induced by statin therapy resolve relatively quickly; however, the results of the PRIMO study showed that it may take up to 2 months for resolution of symptoms.
Has simvastatin been discontinued?
Yesterday the Food and Drug Administration told doctors to stop prescribing the top 80-milligram dose of simvastatin, also known by the brand name Zocor, to new patients because of a heightened risk of muscle pain. This decision will affect millions of patients.
Where is simvastatin made?
It is in the statin class of medications and works by decreasing the manufacture of cholesterol by the liver. Simvastatin is made from the fungus Aspergillus terreus. It was patented by Merck in 1980, and came into medical use in 1992….Simvastatin.
| Clinical data | |
|---|---|
| IUPHAR/BPS | 2955 |
| DrugBank | DB00641 |
| ChemSpider | 49179 |
| UNII | AGG2FN16EV |
Does simvastatin increase blood pressure?
In conclusion, simvastatin promotes a significant reduction of BP in patients with hypertension, particularly in patients with higher levels of total cholesterol. This effect may account for a part of the beneficial effects of statins in the prevention of cardiovascular disease.
Can I take simvastatin every other day?
Background: Statins are generally well tolerated, but some patients discontinue therapy secondary to adverse effects. Dosing a statin (rosuvastatin) every other day (EOD) may provide significant lipoprotein changes while avoiding common adverse effects in this statin-intolerant population.