What is the formulation of aspirin?
Aspirin or acetylsalicylic acid is an acetylated form of salicylic acid with a pKa of 3.5 and a volume of distribution of 0.1 to 0.3 L/kg and is approximately 90% plasma protein bound at therapeutic levels. This acetylation is a necessary component for its antiplatelet effects.
Why is aspirin formulated as coated tablets?
Some drugs like aspirin that have an irritant effect on the GI Track after administration, can be prepared as enteric-coated tablet. Aspirin is used to reduce fever and to relieve pain from various conditions. By coating aspirin tablet with polymer it prevents the stomach bleeding.
What is the difference between aspirin and buffered aspirin?
What makes Bufferin® different than enteric coated and plain aspirin? Bufferin® contains three different buffering agents (calcium carbonate, magnesium carbonate and magnesium oxide) which work together to help neutralize stomach acid and reduce potential irritation associated with aspirin use.
What is the difference between chewable aspirin and enteric-coated?
When it comes to rates of ulceration and bleeding, there’s no difference between enteric-coated and regular aspirin. The risk of ulcers and bleeding probably comes from aspirin’s effects in the bloodstream, rather than from where the drug dissolves and is absorbed.
What is aspirin chemistry?
One of the best known aromatic acetates is acetylsalicylic acid, or aspirin, which is prepared by the esterification of the phenolic hydroxyl group of salicylic acid. Aspirin possesses a number of properties that make it the most often recommended drug. It is an analgesic, effective in pain relief.
Which polymer is used for enteric coating?
Delayed-release (Enteric) Coatings
| Polymer | Comments |
|---|---|
| Cellulose acetate phthalate | Hydrolysis potential – high** |
| Cellulose acetate trimellitate | Hydrolysis potential – medium** |
| Polyvinyl acetate phthalate | Hydrolysis potential – low** |
| Hydroxypropylmethylcellulose phthalate | Hydrolysis potential – medium** |
How do you make aspirin granules?
6. Store prepared granules in well closed and labelled container….
- Weigh and pass aspirin powder through 60# sieve.
- Mix aspirin, citric acid, calcium carbonate and saccharine sodium uniformly in.
- Prepare 10 % PVP solution in ethanol and stir until it becomes clear.
- Add PVP solution dropwise in mortar to get cohesive mass.
What is enteric coating made of?
The substances used in enteric coating are hydroxypropyl methylcellulose phthalate (HPMCP), polyvinyl acetate phthalate, diethyl phthalate, and cellulose acetate phthalate. In general, tablets can be coated using either a fluid-bed dryer or air suspension coating.
What is bufferin used for?
It is used to treat mild pain and fever. This medicine is also used as directed by a doctor to prevent and to treat heart attacks, to prevent strokes and blood clots, and to treat arthritis or inflammation.
What is aspirin 325mg?
Aspirin is used to reduce fever and relieve mild to moderate pain from conditions such as muscle aches, toothaches, common cold, and headaches. It may also be used to reduce pain and swelling in conditions such as arthritis. Aspirin is known as a salicylate and a nonsteroidal anti-inflammatory drug (NSAID).
Is aspirin metabolized by the liver?
As much as 80% of therapeutic doses of salicylic acid is metabolized in the liver.
What is the full chemical equation of aspirin?
The formula of the chemical compound aspirin is C9H8O4
What is the empirical formula of aspirin, C9H8O4?
The empirical formula of Aspirin=C9H8O4. the molar mass of C9H8O4=(9*12)+(8*1)+(4*16) g/mol=180 g/mol. So the empirical formula is also molecular formula for Aspirin.
What is the element formula for aspirin?
Aspirin is a white crystalline powder with a melting point of 135°C. The common chemical name for aspirin is acetylsalicylic acid. Its systematic name is 2-(acetyloxy)benzoic acid. The chemical formula of aspirin is C9H8O4 and the atoms are arranged according to the following diagram.
Should aspirin be used for primary prevention?
Consumers and patients who do not suffer from cardiovascular disease sometimes consider taking aspirin to reduce the possibility of having a heart attack or stroke. Reducing the possibility of having a first heart attack or stroke is called primary prevention.