What is prostaglandin synthesis?
Prostaglandin synthesis is initiated by the interaction of various hormones (e.g. bradykinin, angiotensin II, thrombin) with their cognate cell surface receptors (Figs. 2 and 3). Hormonal stimulation results in the activation of one or more cellular lipases.
Is PGF2 alpha a prostaglandin?
Prostaglandin F2-alpha(PGF-2 alpha) is a stable prostaglandin that stimulates the contraction of uterine and bronchial smooth muscle and produces vasoconstriction (tightening) in some blood vessels. As a pharmaceutical, the generic name of PGF-2 alpha is dinoprost.
How is pgf2a made?
PGF2α can be synthesized from PGH2 via the aldo-keto reductase (AKR) 1C3. AKR1C3 mRNA and protein levels in monkey granulosa cells were low before hCG and peaked 24-36 hours after hCG administration. Human granulosa cells converted PGD2 into 11β-PGF2α, confirming that these cells possess AKR1C3 activity.
What are prostaglandin synthetase inhibitors?
Prostaglandin synthetase inhibitors (PGSIs) prevent the synthesis of prostaglandin, thus reducing uterine hypercontractility, pressure, ischemia, and pain. Improvement also occurs in concurrent symptoms including backache, nausea, vomiting, dizziness, leg pain, insomnia, and headache.
Is thromboxane a prostaglandin?
Prostaglandins (PGs), thromboxanes, and leukotrienes are three classes of arachidonic acid derivatives collectively called eicosanoids. The primary prostaglandins of biological interest are prostaglandin E2 and F2α.
What does prostaglandin D2 do?
Prostaglandin D2 has recently been identified as a factor which is elevated in the bald scalp of men with androgenetic alopecia and has the capacity to decrease hair lengthening. An enzyme which synthesizes it, prostaglandin D2 synthase (PTGDS or lipocalin-PGDS) is hormone responsive in multiple other organs.
What is PGF2a hormone?
PGF2A. : One of the prostaglandins, a group of hormone-like substances that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation.
Where is prostaglandin found?
Prostaglandins are found in most tissues and organs. They are produced by almost all nucleated cells. They are autocrine and paracrine lipid mediators that act upon platelets, endothelium, uterine and mast cells. They are synthesized in the cell from the fatty acid arachidonic acid.
Which drug is inhibitor of prostaglandin?
Aspirin and a large number of nonsteroidal anti-inflammatory drugs act primarily through the inhibition of prostaglandin synthesis by inhibiting the enzyme cyclooxygenase.
What is prostaglandins quizlet?
Prostaglandins. are potent unsaturated fatty acids that act in exceedingly low concentrations on local target organs, found in many tissues. And exert their effects through the (prostaglandin system) central nervous system because of the analgesic and antiinflammatory effects exhibited by these agents.
What kind of hormone is thromboxane?
Thromboxane is a vasoconstrictor and a potent hypertensive agent, and it facilitates platelet aggregation. It is in homeostatic balance in the circulatory system with prostacyclin, a related compound.
Are leukotrienes prostanoids?
Prostanoids, including prostaglandins and thromboxanes, are generated by the phospholipase A2/cyclooxygenase pathway, and leukotrienes are generated by the 5-lipoxygenase pathway from arachidonic acid.