What is interface hepatitis?
Interface hepatitis, formerly known as piecemeal necrosis, can be defined as death of hepatocytes at the interface of parenchyma and the connective tissue of the portal zone, accompanied by a variable degree of inflammation and fibrosis.
What causes interface hepatitis?
Piecemeal necrosis in liver aka interface hepatitis is necrosis of the limiting plates, by inflammatory cells. It may be identified as actual necrosis of cells or by irregularity of the limiting plates which is caused IOS’s hepatocytes and replacement with inflammatory cells and/or fibrosis.
What causes bridging necrosis?
Bridging of terminal hepatic venules to portal tracts (central-portal bridging necrosis) is a fairly common feature of acute hepatitis of viral type, when the bridges contain few or no elastic fibres. It is also seen in exacerbations of chronic hepatitis. Old bridges contain elastic fibres as well as collagen fibres.
What is a florid duct lesion?
The florid duct lesion, defined as a granulomatous destruction of the bile ducts, is the histological hallmark of PBC. The granulomatous inflammation may be either well-formed or vague, and is accompanied by lymphocytes and variable numbers of plasma cells, all of which are centered on the bile duct [6].
What is portal inflammation?
In contrast with the frequently mixed acute and chronic inflammatory infiltrates that may occur in the lobules in NAFLD, portal inflammation is comprised of cells referred to as “chronic”, i.e. lymphocytes, plasma cells, occasional eosinophils, monocytes 4.
What should hepatitis B patients avoid?
Limit foods containing saturated fats including fatty cuts of meat and foods fried in oil. Avoid eating raw or undercooked shellfish (e.g. clams, mussels, oysters, scallops) because they could be contaminated with a bacteria called Vibrio vulnificus, which is very toxic to the liver and could cause a lot of damage.
What are the different types of bridging necrosis?
With more severe injury, necrosis may become confluent involving more than one zone within the lobule and/or extend zonally from one lobule to another adjacent lobule. The latter is termed “bridging necrosis” and can occur in various forms, such as central-central or portal-portal bridging necrosis.
How is APRI score calculated?
The formula for the APRI score is [(AST/upper limit of the normal AST range) X 100]/Platelet Count….How Is It Calculated?
- Divide your AST count by the upper limit of the normal AST range. Most experts say that 40 is a good value to use here.
- Multiply that answer by 100.
- Divide that answer by your platelet count.
What is a florid duct?
Where is bile duct located?
The bile ducts are a series of thin tubes that go from the liver to the small intestine. Their main job is to allow a fluid called bile to go from the liver and gallbladder into the small intestine, where it helps digest the fats in food.
What does it mean to have interface hepatitis?
Interface hepatitis (piecemeal necrosis) is a process of inflammation and erosion of the hepatic parenchyma at its junction with portal tracts or fibrous septa.
What are the pathology features of autoimmune hepatitis?
Comment: In view of hepatitic liver enzyme derangement, serum antinuclear antibody titer (1:320), seropositivity of smooth muscle antibody and elevated serum IgG (1.2 x ULN), the overall features are consistent with autoimmune hepatitis.
How is a hepatitis biopsy used to diagnose ch?
In the setting of a known chronic hepatitis (CH), a biopsy provides information regarding: (1) the extent of ongoing necroinflammatory activity, which is a precursor to fibrogenesis; and (2) the extent of fibrosis. These two variables have drawn comparisons with neoplastic processes and have thus been termed “grade” and “stage,” respectively.
What kind of cells are found in hepatitis C?
Mononuclear infiltration of portal tracts (mostly CD4+ T lymphocytes with some plasma cells) Lymphoid aggregates or follicles may be present (most common in hepatitis C infection) Hepatocyte apoptosis and inflammation at the stromal-parenchymal interface (interface of portal tract and lobule)