How effective is taxol and carboplatin for lung cancer?
To date, the best results have come from the Fox Chase Cancer Center study,[36] which reported an impressive 62% response rate and 54% 1-year survival rate from a regimen involving intrapatient escalation of the paclitaxel dose between 135 and 215 mg/m² and carboplatin dosed to achieve an AUC of 7.5 mg/mL · min.
Is carboplatin the same as Taxol?
Paclitaxel and carboplatin, also known as Taxol/Carbo, is used to treat different cancers including ovarian, womb, cervical and lung cancer.
How is taxol and carboplatin administered?
You have paclitaxel and carboplatin as fluids into a vein (drips). You have paclitaxel over 3 hours and carboplatin between 30 minutes and 1 hour. The whole treatment can take up to 4 hours. You have treatment once every 3 weeks.
What are the side effects of Taxol and carboplatin?
In clinical studies, the most commonly reported side effects of carboplatin + paclitaxel (carbo plus taxol®) are shown here: Low white blood cells. Low red blood cells [Anemia] Hair loss.
What are the long term side effects of carboplatin?
Sensory loss, numbness and tingling, and difficulty in walking may last for at least as long as therapy is continued. These side effects may become progressively more severe with continued treatment, and your doctor may decide to decrease your dose.
What steroids are given with Taxol?
Conventional taxol premedication regimens utilize large amounts of steroids.
Why is taxol given before carboplatin?
Taxol (paclitaxel, Paxel) must be given before carboplatin because if carboplatin is given before Taxol, it stops Taxol from having an effect on cancer cells. This is called a scheduling interaction because when Taxol is given before carboplatin, there is little interaction and both agents work as intended.
Do you lose your hair with carboplatin?
Your hair may get thinner. But you are unlikely to lose all the hair from your head. Hair loss usually starts after your first or second treatment. It is almost always temporary, and your hair will usually grow back after treatment finishes.
Why do you give Taxol before carboplatin?
How long does it take to infuse carboplatin?
Carboplatin is usually given by infusion into a vein (intravenously-IV) over at least 15 minutes by a healthcare professional. The dosage is based on your medical condition, body size, and response to therapy. In general, courses of carboplatin treatment should not be given more often than once every 4 weeks.
Do you lose hair with carboplatin?
How is the carboplatin AUC and dosage calculated?
■ Carboplatin dose based on the Calvert formula is: Dosage = Target AUC x (GFR + 25) Carboplatin and target AUC The carboplatin dosage value is calculated by taking into account the target area concentration versus time curve and estimated GFR.
How often should you take carboplatin and paclitaxel?
Schedule. Carboplatin + paclitaxel is usually given in an outpatient infusion center, allowing the person to go home afterwards. On occasion, carboplatin + paclitaxel may be given in the hospital if someone is too sick. Carboplatin + paclitaxel is repeated every 21 days. This is known as one Cycle.
How long does it take to take carboplatin infusions?
Carboplatin intravenous infusion (I.V.) over at least 15 minutes (commonly 30 or 60 minutes) on Day 1 patient tolerability. Pre-medications and intravenous (I.V.) fluids, such as hydration, may add more time Click here for common starting doses.
How are carboplatin and paclitaxel used to treat ovarian cancer?
Treatment Name: Carboplatin + Paclitaxel (Carbo/Taxol®) Both carboplatin and paclitaxel are designed to kill and slow the growth of cancer cells. Goals of therapy: Carboplatin + paclitaxel (also known as carbo-taxol) is given to shrink tumors and alleviate (lessen) symptoms of ovarian cancer.