How long can Cardizem be out of the fridge?
The vials may be stored at room temperature for 1 month. The single dose syringes (Lyo-ject) should be stored at room temperature between 59 and 86 degrees F (15-30 degrees C). Once the powder has been mixed with the solution, the syringe can be stored at room temperature for 24 hours.
How long does IV diltiazem last?
Following a single intravenous injection in healthy male volunteers, diltiazem hydrochloride appears to obey linear pharmacokinetics over a dose range of 10.5 to 21 mg. The plasma elimination half-life is approximately 3.4 hours.
How do you give diltiazem injection?
Intravenous Administration A common infusion dilution is 125 mg of diltiazem injection added to 100 mL of an appropriate diluent to give a final concentration of 125 mg/125 mL (1 mg/mL). For adult patients, infuse at an initial rate of 10 mg/hr, and increase if necessary to 15 mg/hr.
How do you reconstitute diltiazem?
Continuous Infusion: Diluent: Dilute 125 mg in 100 mL, 250 mg in 250 mL, or 250 mg in 500 mL of 0.9% NaCl, D5W, or D5/0.45% NaCl. Infusion is stable for 24 hr at room temperature or if refrigerated.
How long does it take for IV diltiazem to lower heart rate?
Conclusion: Treatment of acute AFF with i.v. diltiazem decreases ventricular heart rate significantly within 5 minutes, compared with 3 hours for treatment with i.v. digoxin.
Is diltiazem light sensitive?
Photosensitivity reactions associated with the use of diltiazem were reported previously. These cutaneous adverse effects include erythema, pruritus, and/or lichenoid eruptions, which mostly develop soon after exposure to the sun.
How long does it take for diltiazem drip to work?
Diltiazem controls high blood pressure and chest pain (angina) but does not cure them. It may take up to 2 weeks before you feel the full benefit of diltiazem.
How fast do you push diltiazem?
In the standard IV push group, diltiazem will be administered at a dose of 0.25 mg/kg, to a max dose of 25 mg, over 2 minutes.
Does diltiazem need to be diluted?
Dilution: To prepare diltiazem hydrochloride injection for continuous intravenous infusion aseptically transfer the appropriate quantity (see chart) of diltiazem hydrochloride injection to the desired volume of either Normal Saline, D5W, or D5W/0.45% NaCl. Mix thoroughly. Use within 24 hours.
How long does it take for diltiazem to work?
Diltiazem starts to work on the day you start taking it, but for high blood pressure and angina it may take a couple of weeks to work fully. If you’re taking diltiazem for high blood pressure, you may not have had any symptoms before. In this case, you may not feel any different when you take it.
Does diltiazem lower heart rate?
Diltiazem is called a calcium channel blocker. It works by relaxing blood vessels in the body and heart so blood can flow more easily. Diltiazem also lowers your heart rate. These effects help the heart work less hard and lower blood pressure.
How can you protect light sensitive drugs?
Protect from light. Store the vial in the original carton to protect from light. Keep ampules in package until time of use. Drug can be stored in a syringe for up to 8 hours prior to administration but must be protected from direct sunlight.