What is cicatricial pemphigoid?
Cicatricial pemphigoid is a subepidermal blistering disease that involves the mucous membranes and the skin. The oral cavity and the eye are most frequently involved. The clinical course is of long duration, and often there is significant scarring that can have devastating sequelae.
How is cicatricial pemphigoid treated?
The goal of treatment in mucous membrane pemphigoid (MMP) (cicatricial pemphigoid) is to suppress extensive blister formation, promote healing, and prevent scarring. The lowest dose of medication to suppress disease activity and to minimize the risk for the patient should be used.
How is cicatricial pemphigoid diagnosed?
Criteria for the diagnosis of mucous membrane pemphigoid include an appropriate clinical presentation, histology demonstrating a subepidermal blistering process (as described below), and DIF results showing continuous deposits of any one or the combination of the following along the epithelial basement membrane zone: …
Can ocular cicatricial pemphigoid be cured?
Patients may or may not have more than one site affected by the disease, but 70% of the patients with ocular cicatricial pemphigoid have eye involvement. And because this is a systemic autoimmune disease, it cannot be successfully treated, long-term, with simple topical (drops) therapy.
What is Cicatricial?
Scarring, or cicatricial, alopecia is an inflammatory condition in which hair follicles are destroyed, resulting in scarring and permanent hair loss. The Mount Sinai Health System is home to dermatologists who have deep experience diagnosing and treating this form of alopecia.
What does Cicatricial mean?
pl. cic·a·tri·ces (sĭk′ə-trī′sēz, sĭ-kā′trĭ-sēz′) A scar left by the formation of new connective tissue over a healing sore or wound.
What is OCP eye disease?
Ocular cicatricial pemphigoid (OCP) is a form of mucous membrane pemphigoid (MMP) that features chronic, relapsing-remitting bilateral conjunctivitis. Ultimately, patients affected by this autoimmune disease will experience conjunctival cicatrization or scarring.
Is ocular cicatricial pemphigoid an autoimmune disease?
Abstract: : Background: Ocular Cicatricial Pemphigoid (OCP) is a progressive autoimmune disorder, occurring late in life and characterized by recurrent episodes of inflammation, blistering and progressive conjunctival fibrosis that damages normal eye architecture and can lead to blindness; however the etiology of this …
What is OCP in the eye?
Ocular cicatricial pemphigoid (OCP) is a form of mucous membrane pemphigoid (a group of rare, chronic autoimmune disorders) that affects the eyes.
What is a Cicatricial lesion?
Mucous membrane pemphigoid (MMP), also known as cicatricial pemphigoid, refers to a group of rare chronic autoimmune blistering diseases that predominately affect the mucous membranes, including the conjunctiva, and occasionally the skin.
What causes Cicatricial alopecia?
Cicatricial alopecia is primarily caused by inflammation that damages the hair follicle, although the damage may also be caused by a trauma such as a burn or serious infection. The inflammation could involve different types of cells, including lymphocytes, natural killer cells, or a combination of cell types.
What kind of autoimmune disease is cicatricial pemphigoid?
Mucous membrane pemphigoid, known as cicatricial pemphigoid, refers to a group of rare chronic autoimmune blistering diseases that predominately affect the mucous membranes, including the conjunctiva, and occasionally the skin.
How does ocular cicatricial pemphigoid affect the eyes?
Summary Summary. Listen. Ocular cicatricial pemphigoid (OCP) is a form of mucous membrane pemphigoid (a group of rare, chronic autoimmune disorders) that affects the eyes. In the early stages, people with OCP generally experience chronic or relapsing conjunctivitis that is often characterized by tearing, irritation, burning, and/or mucus drainage.
How does cicatricial pemphigoid affect the oral mucosa?
Summary Summary. Cicatricial pemphigoid is a rare, chronic, blistering and scarring disease that affects the oral and ocular mucosa. Other mucosal sites that might be affected include the nasopharnyx, larynx, genitalia, rectum, and esophagus.
Where does pemphigoid occur in the human body?
Pemphigoid can also cause blistering on the mucous membranes. Mucous membranes produce mucus that helps protect inside of the body. Pemphigoid can be found on the mucous membranes in the eyes, nose, mouth, and genitals. It can also occur during pregnancy in some women.