Where is mefenamic acid metabolized?
Mefenamic acid, its metabolites and conjugates are primarily excreted by the kidneys. Both renal and hepatic excretion are significant pathways of elimination.
What is the drug classification of mefenamic acid?
Mefenamic acid is in a class of medications called NSAIDs. It works by stopping the body’s production of a substance that causes pain, fever, and inflammation.
What is the contraindication of mefenamic acid?
Mefenamic acid is contraindicated in patients with salicylate hypersensitivity or NSAID hypersensitivity who have experienced asthma, urticaria, or other allergic reactions after taking aspirin or other NSAIDs. Severe, rarely fatal, anaphylactoid reactions to mefenamic acid have been reported in such patients.
How many mg of mefenamic are in a capsule containing 500mg?
Mefenamic Acid Description Each hard gelatin capsule contains 250 mg of Mefenamic Acid for oral administration. Mefenamic Acid is a white to off white, crystalline powder with a melting point of about 230°C-231°C and water solubility of 0.004% at pH 7.1.
What is Iupac nomenclature of mefenamic acid?
Mefenamic acid is a nonsteroidal antiinflammatory drug (NSAID) used largely for acute treatment of pain….2Biologic Description.
| SVG Image | |
|---|---|
| IUPAC Condensed | Ph(2,3-diMe)-2Abz-OH |
| Sequence | X |
| HELM | PEPTIDE1{[Cc1cccc(c1C)Nc2ccccc2C(=O)O]}$$$$ |
| IUPAC | N-(2,3-dimethylphenyl)-2-aminobenzoic acid |
Is mefenamic acid an analgesic?
Mefenamic acid has analgesic, anti-inflammatory, and antipyretic properties.
How do you calculate mefenamic acid?
- For menstrual cramps: Adults and children 14 years of age and older—At first, 500 milligrams (mg), then 250 mg every 6 hours as needed, for 2 to 3 days.
- For mild to moderate pain: Adults and children 14 years of age and older—At first, 500 milligrams (mg), then 250 mg every 6 hours as needed, for not more than 1 week.
Is mefenamic safe for hypertension?
For people with heart disease, including heart failure and high blood pressure: Mefenamic acid may cause an increased risk of heart problems, including heart attack, stroke, or blood clot. Your risk may be higher if you already have heart disease and take this medication for a longer period of time.
Which is better mefenamic acid or paracetamol?
time curve showed that mefenamic acid demonstrated significantly better antipyretic activity compared to paracetamol (P < 0.05) over the entire period of observation and ibuprofen (P < 0.05) in the 2 to 4 hour range.
What is the action of mefenamic acid?
Mefenamic acid has analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of mefenamic acid, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Mefenamic acid is a potent inhibitor of prostaglandin synthesis in vitro.
What can be the correct Iupac nomenclature of indomethacin?
The chemical name is -(4-chlorobenzoyl)-5-methoxy-2-methyl-1Hindole- 3-acetic acid.
How long should I wait between doses of mefenamic acid?
The first dose is 500 mg. After that, take 250 mg every six hours as needed. You shouldn’t take mefenamic acid for longer than two to three days.
What is the melting point of mefenamic acid?
Mefenamic acid is a white to greyish-white, odorless, microcrystalline powder with a melting point of 230°-231°C and water solubility of 0.004% at pH 7.1. The chemical name is N-2,3-xylylanthranilic acid. The molecular weight is 241.29. Its molecular formula is C15H15NO2and the structural formula of mefenamic acid is:
How is mefenamic acid different from other NSAIDs?
Mefenamic acid, an anthranilic acid derivative, is a member of the fenamate group of nonsteroidal anti-inflammatory drugs (NSAIDs). It exhibits anti-inflammatory, analgesic, and antipyretic activities. Similar to other NSAIDs, mefenamic acid inhibits prostaglandin synthetase.
What are the risks of taking mefenamic acid?
Known hypersensitivity to mefenamic acid or any ingredient in the formulation. History of asthma, urticaria, or other sensitivity reaction precipitated by aspirin or other NSAIAs. In the setting of CABG surgery. Active ulceration or chronic inflammation of upper or lower GI tract. Preexisting renal disease.
How is mefenamic acid used in the treatment of arthritis?
A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase. For the treatment of rheumatoid arthritis, osteoarthritis, dysmenorrhea, and mild to moderate pain, inflammation, and fever.