What is granisetron used for?
Granisetron is used to prevent nausea and vomiting caused by cancer chemotherapy and radiation therapy. Granisetron is in a class of medications called 5-HT3 receptor antagonists. It works by blocking serotonin, a natural substance in the body that causes nausea and vomiting.
What is the mechanism of action of granisetron?
Granisetron is an indazole derivative with antiemetic properties. As a selective serotonin receptor antagonist, granisetron competitively blocks the action of serotonin at 5-hydroxytryptamine3 (5-HT3) receptors, resulting in the suppression of chemotherapy- and radiotherapy-induced nausea and vomiting.
What is the other name for granisetron?
BRAND NAME(S): Kytril. USES: This medication is used to prevent nausea and vomiting due to cancer drug treatment (chemotherapy) and radiation therapy. It works by blocking one of the body’s chemicals (serotonin) that causes vomiting.
What is the difference between ondansetron and granisetron?
Conclusion. Granisetron at an intravenous dose of 2 mg was found to be safe, well tolerated, and more effective by increasing the incidence of complete response compared to 4 mg intravenous ondansetron when used for antiemetic prophylaxis in maxillofacial surgery patients receiving general anesthesia.
What is the generic name for granisetron HCL?
Kytril is a prescription medicine used to treat the symptoms of nausea or vomiting caused by radiation treatment, chemotherapy or postoperative. Kytril may be used alone or with other medications. Kytril belongs to a class of drugs called Antiemetics, Selective 5-HT3 Antagonist.
When do you give granisetron?
To prevent nausea and vomiting caused by surgery, granisetron immediate-release is usually given during surgery. To treat nausea and vomiting caused by surgery, granisetron is given as soon as nausea and vomiting occurs. Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.
How do you give granisetron?
A dose of 1 – 3 mg (10 – 40 µg/kg) of Granisetron should be administered either as a slow intravenous injection or as a diluted intravenous infusion and administered over 5 minutes. The solution should be diluted to 5 ml per mg. Further maintenance doses of Granisetron may be administered at least 10 minutes apart.
What is the Iupac name of granisetron?
Granisetron is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy and radiotherapy….Granisetron.
| Clinical data | |
|---|---|
| show IUPAC name | |
| CAS Number | 109889-09-0 |
| PubChem CID | 3510 |
| IUPHAR/BPS | 2300 [3H]granisetron: 2292 |
How long does granisetron stay in your system?
Sustol (granisetron) is a long-acting medication that can stay in your system for a week after just one dose. How long after receiving a Sustol (granisetron) injection could I see a skin reaction?
How do you administer granisetron?
How long does Emend stay in your system?
This effect can last for up to 28 days after your last dose of this medication. Ask your doctor about using a non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while taking aprepitant and for at least 1 month after your treatment ends.
Can granisetron increase blood pressure?
In most human studies, granisetron has had little effect on blood pressure, heart rate or ECG. No evidence of an effect on plasma prolactin or aldosterone concentrations has been found in other studies.
Granisetron is a serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic for cancer chemotherapy patients. Granisetron is a Serotonin-3 Receptor Antagonist. The mechanism of action of granisetron is as a Serotonin 3 Receptor Antagonist.
Who is the manufacturer of the drug granisetron?
Granisetron was developed by chemists working at the British drug company Beecham around 1988 and is available as a generic. It is produced by Roche Laboratories under the trade name Kytril.
How is granisetron used to treat nausea and vomiting?
Granisetron is an indazole derivative with antiemetic properties. As a selective serotonin receptor antagonist, granisetron competitively blocks the action of serotonin at 5-hydroxytryptamine3 (5-HT3) receptors, resulting in the suppression of chemotherapy- and radiotherapy-induced nausea and vomiting. Drugs used to prevent NAUSEA or VOMITING.
Is there an extended release version of granisetron?
Extended release. An extended release injectable version of granisetron, known as Sustol is also available in the United States as of 2016. The long acting form is used for the treatment of both acute and delayed CINV in moderately emetogenic chemotherapy and anthrocycline and/or cyclophosphamide (AC) highly emetogenic regimens.