What are papillary lesions of the breast?
Papillary lesions are a heterogeneous group of breast lesions that include benign papillomas, atypical papillomas, and papillary carcinomas. Intraductal papilloma usually presents with nipple discharge or a palpable mass, and surgical management is the common procedure.
Is papillary carcinoma the same as DCIS?
The cancer cells’ finger-like appearance is what distinguishes them from cells that would be apparent in other types of breast cancer. Papillary carcinoma is often found with ductal carcinoma in situ (DCIS), which is a type of early stage breast cancer confined to a milk duct.
What is papillary DCIS?
Papillary DCIS also called intraductal carcinoma, is a variant of DCIS and is a term given by the WHO [9]. It is defined as an in situ malignant papillary lesion without recognizable papilloma morphological characteristics.
Is papillary same as papilloma?
Despite the superficial similarities between papillomas and papillary carcinomas, the 2 lesions do not share fundamental properties. Both the stroma and the glands of a papilloma have a neoplastic origin, whereas the glandular cells, alone, constitute the neoplastic component of a papillary carcinoma.
What causes papillary lesion?
The exact cause of them is unknown, but the growths result from cells in the duct growing faster than normal. The overgrowth of cells forms a small lump. Experts believe that your risk of intraductal papilloma may be affected by: Family history of intraductal papilloma.
What is the treatment for encapsulated papillary carcinoma?
Surgical excision is a golden standard in the treatment of papillary lesions and is recommended if the core needle biopsy shows atypia or invasion and in the presence of imaging-histological discordance. Surgery is recommended in all cases when a solid mass in the cyst is seen.
Is solid papillary carcinoma DCIS?
Solid papillary ductal carcinoma in situ (SP-DCIS) shares many morphological features with usual ductal hyperplasia (UDH) involving a papilloma: papillary architecture, solid growth, cellular streaming, and low-grade nuclear features.
Is papilloma benign or malignant?
Papillomas are benign growths. This means that they do not grow aggressively and they do not spread around the body. The growths only form in certain types of tissue, although these tissues occur all over the body. Papillomas are often known as warts and verrucae when they reach the skin.
Can an encapsulated tumor spread?
While many benign tumors remain encapsulated, as a result of genetic mutations acquired during tumor progression, others become malignant by developing the skills necessary to degrade and breach the capsule and then spread rapidly through the surrounding tissue.
What does it mean if a tumor is encapsulated?
Encapsulated: Confined to a specific area. For example, an encapsulated tumor remains in a compact form.
What is invasive solid papillary carcinoma?
In conclusion, invasive solid papillary carcinomas are rare malignant tumours of the breast, the clinical behaviours of which have to be ascertained by further research, though they are said to have aggressive clinical behaviours than those of other carcinomas in the presence of invasive components [7,8].
Is the papillary DCIS an invasive carcinoma?
Elongate hyperchromatic stratified or pseudostratified nuclei perpendicular to stalk Complex arborizing thin, delicate fibrovascular stalks Myoepithelial cells often cannot be demonstrated around the outside of papillary DCIS; however, papillary DCIS is not clinically an invasive carcinoma
Are there any myoepithelial cells in DCIS?
Calponin, SMM-HC, and p63 labeled myoepithelial cells (MECs) in all intraductal papillomas and all micropapillary DCIS cases. The invasive papillary carcinoma cases were uniformly negative for all stains.
When is papillary ductal carcinoma in situ?
Variant: Papillary Ductal Carcinoma In Situ Also known as intracystic papillary carcinoma when it is within a large space
How many papillary carcinomas are there in the world?
We evaluated 25 intraductal papillomas and 18 papillary carcinomas (invasive, 4; micropapillary ductal carcinoma in situ [DCIS], 5; cases originally classified as intracystic/intraductal papillary carcinoma, 9) by calponin, smooth muscle myosin heavy chain (SMM-HC), and p63 immunostains.