What are examples of alpha agonists?
Guanabenz, guanfacine, clonidine, tizanidine, medetomidine, and dexmedetomidine are all α-2 agonists that vary in their potency and affinities for the various α-2 receptor subtypes. Clonidine, tizanidine, and dexmedetomidine have received the greatest clinical use and will be addressed more thoroughly.
What are examples of adrenergic agonists?
Adrenergic Agonists
| Drug | Drug Description |
|---|---|
| Methoxamine | An alpha adrenergic agonist used to treat hypotension. |
| Orciprenaline | A beta-2 adrenergic agonist used to treat bronchospasm, asthma, and COPD. |
| Dobutamine | A beta-1 agonist used to treat cardiac decompensation in patients with organic heart disease or from cardiac surgery. |
What is an alpha specific adrenergic agonist?
Alpha-adrenergic agonists are a class of sympathomimetic agents that selectively stimulates alpha adrenergic receptors. The alpha-adrenergic receptor has two subclasses α1 and α2. Alpha 2 receptors are associated with sympatholytic properties. Alpha-adrenergic agonists have the opposite function of alpha blockers.
What does an alpha adrenergic agonist do?
Alpha-adrenoceptor agonists (α-agonists) bind to α-receptors on vascular smooth muscle and induce smooth contraction and vasoconstriction, thus mimicking the effects of sympathetic adrenergic nerve activation to the blood vessels.
Is norepinephrine an alpha agonist?
So reflect for a moment: If norepinephrine or epinephrine is the neurotransmitter of the sympathetic nervous system and it interacts with all the receptors we just described, then we know that norepinephrine or epinephrine stimulates the alpha, beta-1 and beta-2 receptors and thus it is an alpha agonist, a beta-1 …
Is norepinephrine an adrenergic agonist?
Agonists at adrenergic receptors are either direct-acting or indirect-acting. Catecholamines, norepinephrine, and epinephrine are direct-acting and nonselective adrenergic agonists. Indirect-acting agonists cause the release of the neurotransmitter norepinephrine from sympathetic nerve terminals.
Is epinephrine an alpha agonist?
Is epinephrine an alpha or beta agonist?
Epinephrine (adrenaline) is an endogenous catecholamine with potent α- and β-adrenergic stimulating properties. The α-adrenergic action increases systemic and pulmonary vascular resistance, increasing both systolic and diastolic blood pressure.
Is pseudoephedrine an alpha-1 agonist?
Pseudoephedrine and phenylephrine are Alpha-1 agonists. Mechanism of Action: Alpha-1 agonists stimulate alpha receptors in the respiratory tract, causing constriction of blood vessels and shrinkage of swollen nasal mucous membranes, thus increasing airway patency and reducing nasal congestion.
Is Clonidine an alpha adrenergic?
Clonidine is a centrally acting alpha-2 adrenergic receptor agonist. By stimulating the alpha-2 receptors in the brain, it decreases sympathetic outflow leading to a decrease in blood pressure. Clonidine is FDA-approved for treating hypertension in adults and attention deficit hyperactivity disorder (ADHD) in children.
Is Clonidine an alpha 2 agonist?
Alpha 2 receptor agonists such as clonidine or guanabenz reduce central and peripheral sympathetic overflow and via peripheral presynaptic receptors may reduce peripheral neurotransmitter release. Alpha 2 agonists lower blood pressure in many patients either alone or in combination with diuretics.
Is norepinephrine an agonist or antagonist?
Norepinephrine
| Clinical data | |
|---|---|
| Agonists | sympathomimetic drugs, clonidine, isoprenaline |
| Antagonists | Tricyclic antidepressants, beta blockers, antipsychotics |
| Precursor | dopamine |
| Biosynthesis | dopamine β-monooxygenase |
Which is an example of an alpha adrenergic agonist?
Adrenergic alpha-agonists (or alpha-adrenergic agonists) are a class of sympathomimetic agents that selectively stimulates alpha adrenergic receptors. The alpha-adrenergic receptor has two subclasses α1 and α2. Selected examples are: Methoxamine. Midodrine. Metaraminol. Phenylephrine. Amidephrine.
How are alpha adrenergic agonists used in glaucoma treatment?
Alpha-adrenergic agonists, more specifically the auto receptors of alpha 2 neurons, are used in the treatment of glaucoma by decreasing the production of aqueous fluid by the ciliary bodies of the eye and also by increasing uveoscleral outflow.
Are there any nonspecific agonists for alpha-1 receptors?
Nonspecific agonists act as agonists at both alpha-1 and alpha-2 receptors. The following agents are also listed as agonists by MeSH.
Which is an example of a sympathomimetic agonist?
Alpha- and Beta-Adrenergic Agonists Alpha- and beta- agonists are drugs that are generally sympathomimetic. These agonists stimulate all of the adrenergic receptors so they affect both alpha- and beta-receptors. Popular examples of drugs under this class include dopamine, dobutamine, and epinephrine.