What is an NY-ESO-1 receptor?

What is an NY-ESO-1 receptor?

NY-ESO-1 is an archetypical example of a CTA with restricted expression to germ cells and placental cells and re-expression in tumor cells. During embryonic development, NY-ESO-1 expression can be detected as early as 13 weeks and is the highest at 22–24 weeks (20).

What does NY-ESO-1 mean?

The CTA New York Esophageal Squamous Cell Carcinoma-1 (NY-ESO-1) is also known as cancer-testis antigen 1B (CTAG1B) and is encoded by the gene CTGAG1B which is located on the Xq28 region of the X chromosome.

What is DMF5?

Anti-MART-1 T cell receptor (DMF5), pCDTCR1 (TCR-L128) All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease. The vector of anti-MART-1 T cell receptor (TCR) is constructed for the engineering of T cell to target Human MART-1.

What antigen means?

An antigen is any substance that causes your immune system to produce antibodies against it. This means your immune system does not recognize the substance, and is trying to fight it off. An antigen may be a substance from the environment, such as chemicals, bacteria, viruses, or pollen.

What are the 3 types of antigens?

There are three main types of antigen The three broad ways to define antigen include exogenous (foreign to the host immune system), endogenous (produced by intracellular bacteria and virus replicating inside a host cell), and autoantigens (produced by the host).

What is antigen and antibody definition?

The Role of Antigens & Antibodies in Vaccinations. Vaccines contain antigens which stimulate the B lymphocytes of the immune system to respond by producing plasma cells which secrete disease specific antibodies (Primary response).

What is an antigen defined as?

An antigen is any substance that causes your immune system to produce antibodies against it. An antigen may be a substance from the environment, such as chemicals, bacteria, viruses, or pollen. An antigen may also form inside the body.

What are T cells definition?

A type of white blood cell. T cells are part of the immune system and develop from stem cells in the bone marrow. They help protect the body from infection and may help fight cancer. Also called T lymphocyte and thymocyte.

What is an antibody simple definition?

Listen to pronunciation. (AN-tee-BAH-dee) A protein made by plasma cells (a type of white blood cell) in response to an antigen (a substance that causes the body to make a specific immune response). Each antibody can bind to only one specific antigen.

What are the 4 types of T cells and their functions?

T Cell Activation

• Effector Cells. Depending on the APC a naïve cell comes across it can become an effector T cell.
• Cytotoxic T Cells. Cytotoxic T Cells, also known as CD8+ cells, have the primary job to kill toxic/target cells.
• Helper T Cells.
• Regulatory T Cells.
• Memory T Cells.
• Applications.

Where is NY-ESO-1 expressed in the body?

NY-ESO-1 is a cancer/testis antigen expressed in normal adult tissues solely in the testicular germ cells of normal adults and in various cancers. It induces specific humoral and cellular immunity in patients with NY-ESO-1-expressing cancer.

How is NY-ESO-1 mRNA expression in breast cancer?

In the latter case, expression level of NY-ESO-1 mRNA relative to that in the testis was relatively high (75% of testicular expression) and to the other among breast cancer specimens. In benign breast lesions, 21 of 31 (68%) specimens expressed low levels of NY-ESO-1 mRNA.

How is NY-ESO-1 used to treat melanoma?

NY-ESO-1, one of the CT antigens, appears to be strongly immunogenic and is known to induce an efficient humoral immune response in patients with melanoma and other tumor types (6 , 7) . Approximately 50% of patients with advanced NY-ESO-1 mRNA-positive melanoma produce NY-ESO-1 antibody.

How much cDNA is used for NY-ESO-1?

In the NY-ESO-1 cDNA-specific real-time quantitative PCR assay, the reaction mixture contained 250 n m of ESO1-forward and 250 n m of ESO1-reverse primers, 200 n m TaqMan probe, 25 μl TaqMan Universal PCR Master Mix (Applied Biosystems, Foster City, CA), and 1 μl of cDNA, in a total reaction volume of 50 μl.