What does apoB gene do?
ApoB is the main protein of chylomicrons, LDL and VLDL, and acts as a ligand for LDL receptors for cholesterol uptake and LDL catabolism in various cell types of the body.
Do humans have apoB gene?
Apolipoprotein B (apoB): This is the quintessential lipoprotein of the chylomicron. There are two apoB gene products in mice and humans: apoB48 and apoB100.
What are normal Abolipoprotein B levels?
Normal levels of ApoB-100 in adults are less than 100 mg/dL. Your risk is high if you have a result greater than 110 mg/dL. High levels of ApoB may mean that you have a higher than normal risk of developing cardiovascular disease. An ApoA test (linked with “good” cholesterol) may also be done with the ApoB test.
What chromosome is APOB?
Apolipoprotein B
| APOB | ||
|---|---|---|
| Location (UCSC) | Chr 2: 21 – 21.04 Mb | Chr 12: 7.98 – 8.02 Mb |
| PubMed search | ||
| Wikidata | ||
| View/Edit Human View/Edit Mouse |
Where is APOB found?
ApoBs are proteins found in lipoprotein particles that are artery-clogging. The apoB-containing lipoprotein particles that are the most damaging to our arteries include not only LDL cholesterol but also remnants of chylomicrons and VLDL (very low density lipoproteins).
Does all LDL have apoB?
Because there is one apoB per LDL particle, regardless of density, apoB detects the presence of these atherogenic particles, in contrast to LDL cholesterol, and thus may be better suited to guide lipid-lowering therapy, particularly in insulin resistance and type 2 diabetes.
How do I lower my apoB?
How To Lower ApoBs. Consuming less dietary fat and cholesterol and many more fiber-rich, whole plant foods, which is essentially the Pritikin Eating Plan, will greatly reduce the amount of chylomicrons and their atherogenic, apoB-48-containing lipoproteins in the blood.
What is a good ApoB number?
100 mg/dL
What Is an Optimal Number For ApoB? Usually, an apoB of less than 100 mg/dL is considered desirable in low-risk individuals. Less than 80 mg/dL is desirable in high-risk individuals, such as those with cardiovascular disease or diabetes. But rarely are apoB numbers included in standard lipid blood tests.
What does high ApoB mean?
What does the test result mean? Elevated levels of apo B correspond to elevated levels of LDL-C and to non-HDL-C and are associated with an increased risk of cardiovascular disease (CVD). Elevations may be due to a high-fat diet and/or decreased clearing of LDL from the blood.
What is familial Hypobetalipoproteinemia?
Familial hypobetalipoproteinemia (FHBL) is a disorder that impairs the body’s ability to absorb and transport fats. This condition is characterized by low levels of a fat-like substance called cholesterol in the blood . The severity of signs and symptoms experienced by people with FHBL vary widely.
Do Statins lower apoB?
Statins reduce circulating concentrations of atherogenic apoB-containing lipoproteins by decreasing the production of VLDL in the liver and, thus, the production of VLDL remnants and LDL. Statins also increase the clearance of these particles through upregulation of LDL receptors in the liver.
Do Statins lower Apo B?
What is the function of the APOB gene?
Gene function. The APOB gene encodes the apolipoprotein B protein. This protein is part of the lipoprotein complex, which are proteins that carry fats and cholesterol in the blood.
Where does ApoB occur in the human body?
This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA.
Why is ApoB48 called an apolipoprotein instead of ApoB100?
As a result of the RNA editing, ApoB48 and ApoB100 share a common N-terminal sequence, but ApoB48 lacks ApoB100’s C-terminal LDL receptor binding region. In fact, ApoB48 is so-called because it constitutes 48% of the sequence for ApoB100.
What kind of diseases are associated with apoB?
APOB (Apolipoprotein B) is a Protein Coding gene. Diseases associated with APOB include Hypobetalipoproteinemia, Familial, 1 and Hypercholesterolemia, Familial, 2 . Among its related pathways are Vesicle-mediated transport and Selenium Micronutrient Network .