Why is cyclohexylamine toxic?
The corrosive effect of cyclohexylamine is due to its alkalinity; sympathomimetic and cardiovascular effects have been described for it (Barger and Dal 1910). In addition, it releases catecholamine and histamine (Miyata et al.
Is cyclohexylamine toxic?
(4) The effect of the substance on human health. Cyclohexylamine is a severe eye, skin, and respiratory irritant, and is toxic when taken in by any route, including dermal, ingestion, inhalation, mucous membranes (IPCS, 1993).
Which is more basic ammonia or cyclohexylamine?
Cyclohexylamine is more basic than ammonia. Cyclohexylamine is thus more basic than ammonia because alkyl groups are electron-donating (through the effect of hyperconjugation). The cyclohexyl group makes the N atom more nucleophilic than in ammonia, and hence more basic.
How is cyclohexylamine made?
Cyclohexylamine is produced by two routes, the main one being the complete hydrogenation of aniline using some cobalt- or nickel-based catalysts: C6H5NH2 + 3 H2 → C6H11NH. It is also prepared by alkylation of ammonia using cyclohexanol.
Is cyclohexylamine flammable?
Highly flammable. Sensitive to air and light. Soluble in water. CYCLOHEXYLAMINE neutralizes acids in exothermic reactions to form salts plus water.
Where is aniline used?
Aniline is used in rubber accelerators and anti-oxidants, dyes and intermediates, photographic chemicals, as isocyanates for urethane foams, in pharmaceuticals, explosives, petroleum refining; and in production of diphenylamine, phenolics, herbicides and fungicides.
Why is cyclohexylamine basic?
Aniline and cyclohexylamine both hane NH2 group and six carbon ring but the difference in basicity lies in a manner that aniline is a weak base then cyclohexylamine because aniline is an aromatic ring, because of the electron-withdrawing effect of the phenyl group aniline is a weak base.
Is cyclohexylamine soluble in water?
Cyclohexylamine
| Names | |
|---|---|
| Solubility in water | Miscible |
| Solubility | very soluble in ethanol, oil miscible in ethers, acetone, esters, alcohol, ketones |
| Vapor pressure | 11 mmHg (20° C) |
| Acidity (pKa) | 10.64 |
How is cyclohexylamine toxic to the human body?
It is toxic by both ingestion and inhalation; the inhalation itself may be fatal. It readily absorbs through skin, which it irritates. It is corrosive. Cyclohexylamine is listed as an extremely hazardous substance as defined by Section 302 of the U. S. Emergency Planning and Community Right-to-Know Act.
What kind of applications can cyclohexylamine be used for?
Applications. Cyclohexylamine is used as an intermediate in synthesis of other organic compounds. It is the precursor to sulfenamide -based reagents used as accelerators for vulcanization. It is a building block for pharmaceuticals (e.g., mucolytics, analgesics, and bronchodilators ). The amine itself is an effective corrosion inhibitor.
What is the formula for cyclohexylamine in Formula?
Cyclohexylamine is listed as an extremely hazardous substance as defined by Section 302 of the U. S. Emergency Planning and Community Right-to-Know Act. A family of alicyclic hydrocarbons containing an amine group with the general formula R-C6H10NH2.
What kind of odor does cyclohexylamine have in water?
Cyclohexylamine is an organic compound, belonging to the aliphatic amine class. It is a colorless liquid, although, like many amines, samples are often colored due to contaminants. It has a fishy odor and is miscible with water.