What is the incidence of osteosarcoma in the general population?
Use the menu to see other pages. This year, in the United States, an estimated 1,000 people of all ages will be diagnosed with osteosarcoma. About half of these cases will occur in children and teens. Osteosarcoma makes up 2% of all cancers in children ages 0 to 14 and 3% of all cancers in teens ages 15 to 19.
What is the standard treatment for osteosarcoma?
The standard of care for osteosarcoma is currently neoadjuvant chemotherapy, surgery, and adjuvant chemotherapy. The four chemotherapy agents that are in nearly all treatment regimens include methotrexate with leucovorin rescue, doxorubicin, cisplatin, and ifosfamide.
What is the most common treatment for osteosarcoma?
Osteosarcoma is often treated with a combination of therapies that can include surgery, chemotherapy and radiation therapy. Most patients with high grade tumors receive about three months of chemotherapy, known as neo-adjuvant therapy, before surgery.
What are the variants of osteosarcoma?
The list of variants of osteosarcoma includes telangiectatic osteosarcoma, small cell osteosarcoma, high-grade surface osteosarcoma, secondary osteosarcoma, low-grade intraosseous osteosarcoma, parosteal osteosarcoma, and periosteal osteosarcoma.
What is meant by 5-year survival rate?
The percentage of people in a study or treatment group who are alive five years after they were diagnosed with or started treatment for a disease, such as cancer. The disease may or may not have come back.
What’s the survival rate of osteosarcoma?
Osteosarcoma 5-year relative survival rates
| SEER stage | 5-year relative survival rate |
|---|---|
| Localized | 74% |
| Regional | 66% |
| Distant | 27% |
| All SEER stages combined | 60% |
What is the survival rate of osteosarcoma?
How often is chemo given for osteosarcoma?
A commonly recommended course of osteosarcoma chemotherapy regimen consists of approximately six five-week cycles, each of which includes: The administration of a combination of osteosarcoma chemotherapy drugs, such as cisplatin and doxorubicin; ifosfamide and etoposide; or ifosfamide, cisplatin and epirubicin.
Is chemotherapy Effective for osteosarcoma?
The drugs are usually given into a vein and can reach and destroy cancer cells throughout the body. Chemo is an important part of the treatment for most people with osteosarcoma (although some patients with low-grade osteosarcoma might not need it).
What is a Chondroblastoma?
A chondroblastoma is a rare type of noncancerous bone tumor that begins in cartilage. This is the tough, rubbery connective tissue from which most bones develop. It plays an important role in the growth process. There are many different types of cartilage in the body.
What is high grade conventional osteosarcoma?
High grade surface osteosarcoma is a type of high grade osteosarcoma that develops on the surface of the bone from the outer cortex. The microscopic pathology is the same as a conventional osteosarcoma and it has the same high potential for metastasizing.
What are the signs and symptoms of osteosarcoma?
Signs and symptoms of osteosarcoma may include, among others: Swelling near a bone. Bone or joint pain. Bone injury or bone break for no clear reason.
Is there a male predominance in osteosarcoma?
There is a slight male predominance. Secondary osteosarcoma occurs in the elderly, usually secondary to malignant degeneration of Paget disease, extensive bone infarcts, post-radiotherapy for other conditions, osteochondroma, and osteoblastoma.
Can a skip Metastase be a high grade osteosarcoma?
High-grade osteosarcomas may occasionally present with skip metastases, which are non-contiguous smaller tumor foci in the same bone or in adjacent bone 11. The WHO classification of bone tumors lists the histologic types of osteosarcoma, which can be further organized by the state of underlying bone and site of origin within the bone:
What kind of bone cancer is periosteal osteosarcoma?
Periosteal osteosarcoma: an intermediate grade malignant bone and cartilage forming neoplasm arising on the cortical surface of a bone (the periosteum) There may be chondroblastic or fibroblastic differentiation