What medications are based on pyrazole?

[3] Many pyrazole derivatives has already found their application as nonsteroidal anti-inflammatory drugs clinically, such as anti-pyrine or phenazone (analgesic and antipyretic), metamizole or dipyrone (analgesic and antipyretic), aminopyrine or aminophenazone (anti-inflammatory, antipyretic, and analgesic).

What is pyrazole used for?

Pyrazole being a heterocyclic motif has secured an eccentric status in the field of medicinal chemistry. Pyrazole and its derivatives have tremendous biological applications like anti-cancer, anti-microbial, antiviral, antifungal, anti-inflammatory, analgesic, insecticidal etc.

What is pyrazole derivative?

Pyrazole derivatives play an important role in antitumor agents because of their good inhibitory activity against BRAF(V600E), EGFR, telomerase, ROS Receptor Tyrosine Kinase and Aurora-A kinase. In addition, pyrazole derivatives also show good antiinflammatory and anti-bacterial activities.

How do you make pyrazole?

Pyrazole or isoxazole derivatives are prepared by a palladium-catalyzed four-component coupling of a terminal alkyne, hydrazine (hydroxylamine), carbon monoxide under ambient pressure, and an aryl iodide.

What is pyrazole structure?

Pyrazole is a heterocyclic organic compound characterized by a ring structure composed of three carbon atoms and two nitrogen atoms in adjacent positions, with the molecular formula C3H4N2. NCI Thesaurus (NCIt) 1H-pyrazole is the 1H-tautomer of pyrazole. It is a conjugate base of a pyrazolium.

What is the molecular weight of 1/3 pyrazole?

222.026
4-iodo-1,3-dimethyl-1H-pyrazole

CAS Number	6647-97-8
Size	1g, 5g, 10g, 25g
Molecular Weight	222.026
Molecular Formula	C5H7IN2
Purity	97%

What is a pyrazole ring?

What is the structure of pyrazole?

C3H4N2
Pyrazole/Formula

Is pyrazole a base?

Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C). Pyrazoles are also a class of compounds that have the ring C3N2 with adjacent nitrogen atoms.

How will u prepare 1/3 pyrazole?

Principle: 1,3-substituted pyrazole is prepared by cyclization of diarylhydrazone and vicinal diol in presence of ferric chloride and tert-butylhydroperoxide(TBHP) which is also called regioselective synthesis of substituted pyrazole.

What are the properties of pyrazole?

It is a heterocycle characterized by a 5-membered ring of three carbon atoms and two adjacent nitrogen atoms. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C)….Pyrazole.

Names
Chemical formula	C3H4N2
Molar mass	68.079 g·mol−1
Melting point	66 to 70 °C (151 to 158 °F; 339 to 343 K)

Why is pyrazole less basic?

Explain why pyrazole is a weaker base than imidazole. Answer: The sp2 orbital of nitrogen is the site of protonation in both pyrazole and imidazole. The nitrogen atom bonded to hydrogen is not basic because its lone pair of electrons is part of the aromatic ring system.

What kind of base does a pyrazole have?

Pyrazole is a weak base, with p Kb 11.5 (p Ka of the conjugated acid 2.49 at 25 °C). Pyrazoles are also a class of compounds that have the ring C 3 N 2 with adjacent nitrogen atoms. Notable drugs containing a pyrazole ring are celecoxib (Celebrex) and the anabolic steroid stanozolol.

How is the pyrazole ring vulnerable to electrophilic attack?

The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C 3 – and C 5 -positions leaving electron density of C 4 -position unaltered. Thus the C 4 -position is vulnerable to electrophilic attack.

Why are 3 Substituted pyrazoles so inactivity?

Steric interactions are probably responsible for the poor activity of the 3-substituted pyrazoles, while the inability of the N-1 substituted compounds to lose a proton may explain their inactivity.

Can a pyrazole derivative be used as an anticancer agent?

The application of pyrazole derivatives in the development of anticancer agents has been thoroughly investigated and verified [49].