What is Marchiafava Bignami disease?
Abstract. Marchiafava-Bignami disease is a rare affliction characterized by primary degeneration of the corpus callosum associated with chronic consumption of ethanol. The disease may occasionally occur in patients who are not alcoholics but are chronically malnourished.
What is MB syndrome?
MB disease is a rare disorder which typically causes degeneration of the corpus callosum which can range from demyelination to frank necrosis on pathological examination.
What is Wernicke Korsakoff syndrome symptoms?
Symptoms include mental confusion, vision problems, coma, hypothermia, low blood pressure, and lack of muscle coordination (ataxia). Korsakoff syndrome (also called Korsakoff’s amnesic syndrome) is a memory disorder that results from vitamin B1 deficiency and is associated with alcoholism.
What is the cause of Alexander disease?
About 95% of Alexander disease cases are caused by mutations in a gene called GFAP for a structural protein called glial fibrillary acidic protein that is found exclusively in astrocytes in the CNS. The cause of the other 5% of cases is not known. The GFAP mutations are dominant.
What is metachromatic leukodystrophy?
Metachromatic leukodystrophy is a rare hereditary (genetic) disorder that causes fatty substances (lipids) to build up in cells, particularly in the brain, spinal cord and peripheral nerves. This buildup is caused by a deficiency of an enzyme that helps break down lipids called sulfatides.
What does a wet brain mean?
Wet brain is the informal name for Wernicke Korsakoff psychosis` syndrome, which is a type of brain disease caused by undue alcohol consumption. This syndrome (wet brain) is hazardous when caused by excessive alcohol consumption.
Can wet brain get worse?
In its further stages, wet brain will cause severe memory loss that can be similar to Alzheimer’s disease, hallucinations, and psychosis. People who have severe wet brain may never recover, and they may not be able to live an independent life ever again.
Is Wernicke reversible?
In conclusion, Wernicke-Korsakoff syndrome is a reversible and treatable, highly underdiagnosed syndrome with high mortality rates. Rapid diagnosis, timely interventions, and higher effective thiamine doses result in better outcomes.
Is there a cure for Alexander’s disease?
There is no cure for Alexander disease, nor is there a standard course of treatment. Treatment of Alexander disease is symptomatic and supportive. The prognosis for individuals with Alexander disease is generally poor. Most children with the infantile form do not survive past the age of 6.
Is Alexander disease inherited?
This condition is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. Most cases result from new mutations in the gene.