Is leucine a zipper transcription factor?
Basic-region leucine zipper (bZIP) proteins are one of the largest transcription factor families that regulate a wide range of cellular functions. Owing to the stability of their coiled coil structure leucine zipper (LZ) domains of bZIP factors are widely employed as dimerization motifs in protein engineering studies.
What is basic leucine zipper transcription factor?
The basic leucine zipper (bZIP) transcription factors are sequence-specific DNA-binding proteins that regulate transcription. They are characterized by a 60-80 amino acid bZIP domain: a basic DNA binding domain followed by a leucine zipper dimerization domain.
What proteins do transcription factors interact with?
Large proteins that bind to the basal transcription apparatus bind many transcription factors and thus act as integrators of gene transcription. These coactivator molecules include CREB-binding protein (CBP), and the related p300, thus allowing complex interactions between different signaling pathways [14].
Which of the following proteins are likely to contain leucine zipper domain?
Leucine zipper regulatory proteins include c-fos and c-jun (the AP1 transcription factor), important regulators of normal development, as well as myc family members including myc, max, and mxd1.
What does the leucine zipper do?
The Leucine Zipper and the Basic DNA-Binding Domain (bZIP) This leucine zipper facilitates the dimerization of the protein by interdigitation of two leucine containing helices on different molecules and these residues form the buried subunit interface of the coiled-coil dimer.
Which of the following proteins are likely to contain leucine zipper domains?
Are repressor proteins transcription factors?
Transcription factors are proteins that help turn specific genes “on” or “off” by binding to nearby DNA. Transcription factors that are activators boost a gene’s transcription. Repressors decrease transcription.
Are proteins transcription factor?
Transcription factors are proteins involved in the process of converting, or transcribing, DNA into RNA. Transcription factors include a wide number of proteins, excluding RNA polymerase, that initiate and regulate the transcription of genes. Regulation of transcription is the most common form of gene control.
Why is a leucine zipper called a zipper?
This class of DNA binding proteins gets its name from the regular pattern of leucine residues within the two alpha helices (pictured below on the right). Being hydrophobic, the leucines cause two adjacent alpha helices to be “zippered” together by hydrophobic interactions.
How many bZIP transcription factors are there in Arabidopsis?
In plants, basic region/leucine zipper motif (bZIP) transcription factors regulate processes including pathogen defence, light and stress signalling, seed maturation and flower development. The Arabidopsis genome sequence contains 75 distinct members of the bZIP family, of which approximately 50 are not described in the literature.
How does HY5 regulate lazy4 expression in Arabidopsis?
Light modulates the gravitropic responses through organ-specific PIFs and HY5 regulation of LAZY4 expression in Arabidopsis. HY5 Interacts with the Histone Deacetylase HDA15 to Repress Hypocotyl Cell Elongation in Photomorphogenesis. HY5 and MYC2 work in an antagonistic manner in Arabidopsis seedling development.
Which is a cofactor of the HY5 transcription factor?
Identification of BBX proteins as rate-limiting cofactors of HY5. Light controls stamen elongation via cryptochromes, phytochromes and COP1 through HY5 and HYH. Light-regulated expression of terpene synthase gene, AtTPS03, is controlled by the bZIP transcription factor, HY5, in Arabidopsis thaliana.
Which is transcription factor regulates APS reductase expression by light?
A possible interplay between PFT1 and another transcription factor, HY5, may regulate induction of APS reductase expression by light. Data indicate that the PIF1/PIF3-HY5/HYH transcriptional modules mediate crosstalk between light and ROS signaling and a mechanism by which plants adapt to the light environments.