What does Stat5 do?
Stat5 proteins modulate gene transcription upon cytokine- and growth factor action. Stat5a and Stat5b proteins alone are weak activators of transcription. They can modify chromatin organization through oligomerization and they act predominantly in co-operation and interaction with other proteins.
What does Stat5 activate?
The activation of Stat5 proteins (Stat5a and Stat5b) is one of the earliest signaling events mediated by IL-2 family cytokines, allowing the rapid delivery of signals from the membrane to the nucleus. Among STAT family proteins, Stat5a and Stat5b are the two most closely related STAT proteins.
How does STAT5 mediate signaling in the JAK STAT pathway?
IL-2 receptors have γ (gamma) chains, which are associated with JAK3, which then phosphorylates key tyrosines on the tail of the receptor. Phosphorylation then recruits an adaptor protein called Shc, which activates the MAPK/ERK pathway, and this facilitates gene regulation by STAT5.
What is STAT5 in biology?
Signal transducer and activator of transcription 5 (STAT5) refers to two highly related proteins, STAT5A and STAT5B, which are part of the seven-membered STAT family of proteins. STAT5 proteins are involved in cytosolic signalling and in mediating the expression of specific genes.
What is the STAT3 pathway?
STAT3 signaling is a major intrinsic pathway for cancer inflammation because it is often activated in tumor-associated immune and inflammatory cells as well as malignant cells and is capable of inducing a large number of genes that are crucial for inflammation including IL-6, 10, 11, 17, 23, CXCL12, and COX-2 [127].
Where does JAK-STAT pathway occur?
The JAK-STAT system consists of three main components: (1) a receptor (green), which penetrates the cell membrane; (2) Janus kinase (JAK) (yellow), which is bound to the receptor, and; (3) Signal Transducer and Activator of Transcription (STAT) (blue), which carries the signal into the nucleus and DNA.
What activates JAK-STAT pathway?
Triggering the Signal: Receptors. JAK/STAT signaling begins with the activation of JAK by binding of a ligand such as growth factors, interferons, or interleukins to specific transmembrane receptors. A wide array of receptors has been associated with JAK/STAT pathway activation, which are summarized in Table 2.
What is a STAT3 inhibitor?
Specific STAT3 direct inhibitors consist of SH2 ligands, including G quartet oligodeoxynucleotides (ODN) and small molecules, they induce cell death in tumor cells in which STAT3 is activated. STAT3 can also be inhibited by decoy ODNs (dODN), which bind STAT3 and induce cell death.
What does STAT3 stand for?
STAT3 GOF disease is named after the gene that causes it, STAT3 (signal transducer and activator of transcription 3), and the effect caused by mutations in STAT3—gain-of-function, meaning that the gene’s protein becomes overactive.
What is the role of STAT3 / miR-211 / STAT5a signaling?
STAT3/miR-211/STAT5A signaling plays a key role in mesenchymal stem cell migration. Stat5 activation increased the DNA binding activity of NF-kappaB though binding of p-Stat5 and p-RelA in nucleus.
What is the role of STAT5 in Paneth cells?
STAT5 may be a transcription factor that regulates Paneth cells to maintain niche regeneration. Mechanism for IL-15-Driven B Cell Chronic Lymphocytic Leukemia Cycling: Roles for AKT and STAT5 in Modulating Cyclin D2 and DNA Damage Response Proteins.
What is the STAT5 signal in BA / f3-wt cells?
STAT5A/B signal in parental Ba/F3 cells corresponds to endogenous STAT5 protein levels, while the signals detected in the stable cell lines Ba/F3-WT and Ba/F3-1*6 represent both endogenous (STAT5A and STAT5B) and transgenic (STAT5A-WT or -1*6) proteins. b STAT5-mediated expression of c – Myc in Ba/F3-WT and -1*6 cells.
What is the role of STAT5a in breast cancer?
Wild-type FLT3 and FLT3 ITD exhibit similar ligand-induced internalization characteristics. A Bioinformatic Pipeline Places STAT5A as a miR-650 Target in Poorly Differentiated Aggressive Breast Cancer. STAT5A reprograms fatty acid metabolism and promotes tumorigenesis of gastric cancer cells.