Does valproate cause SIADH?

Does valproate cause SIADH?

We conclude that sodium valproate can cause an SIADH-like syndrome with hyponatremia and that serum sodium levels have to be monitored during treatment with high dosages of this drug.

Does valproic acid affect sodium levels?

Hyponatremia is a very commonly encountered clinical entity with potentially dangerous effects and for which many precipitating factors have been identified. We present a case of valproic acid (VPA) overdose causing profound hyponatremia, with one of the lowest serum sodium levels ever documented in literature.

Does Depakote cause SIADH?

Administration of high doses of the mood stabilizer and antiepileptic drug sodium valproate can cause an SIADH-like syndrome with hyponatremia. We recommend that sodium levels be monitored regularly during administration of high doses of sodium valproate.

What are the side effects of valproate?

Common side effects

• stomach pain, feeling or being sick.
• diarrhoea.
• dry or sore mouth, or swollen gums.
• shakes (tremors) in a part of your body, or unusual eye movements.
• feeling tired or sleepy.
• headache.
• weight gain.
• thinning hair, or changes to the colour or texture of your hair.

Does sodium valproate increase sodium levels?

Upon tapering of the dose of sodium valproate, the sodium level started to normalize. After sodium valproate treatment was stopped completely, the sodium level returned to within normal limits, associating the sodium valproate as a cause of the hyponatremia, the hyponatremia probably being due to SIADH.

Does phenytoin cause low sodium?

Phenytoin has been shown to inhibit the release of antidiuretic hormones [19] and has been thought not to induce hyponatremia. However, we found an increased risk of hyponatremia in patients using phenytoin (adjusted OR 1.68) but when analyzing newly initiated vs.

How does lithium cause Siadh?

Both demeclocycline and lithium carbonate can cause a state of nephrogenic DI by interfering with the renal action of ADH. Both drugs interfere with the cellular action of ADH by preventing the formation of cyclic 3′,5′ adenosine monophosphate (cAMP) and the subsequent action of cAMP on the renal tubules.

Does Tegretol cause Siadh?

One cause of hyponatremia, the syndrome of inappropriate antidiuretic hormone (SIADH) secretion, has been associated with some drugs, including carbamazepine (CBZ). Because of its antidiuretic effects, CBZ has been used successfully to treat diabetes insipidus centralis.

Can a high dose of sodium valproate cause SIADH like syndrome?

Repeated water loading tests performed at different dosages of this drug confirmed that the ability to excrete water was reduced in a dose dependent manner. We conclude that sodium valproate can cause an SIADH-like syndrome with hyponatremia and that serum sodium levels have to be monitored during treatment with high dosages of this drug.

Can a valproic acid overdose cause hyponatremia?

Abstract. Hyponatremia is a very commonly encountered clinical entity with potentially dangerous effects and for which many precipitating factors have been identified. We present a case of valproic acid (VPA) overdose causing profound hyponatremia, with one of the lowest serum sodium levels ever documented in literature.

What was the sodium level after stopping valproate?

His admission laboratory data revealed the following serum levels: sodium 127 mmol and sodium valproate 36.9 mg/L. Upon stopping the sodium valproate, the sodium level returned to 140 mmol/L, which was within normal limits.

What are the causes of isovolemic hyponatremia ( SIADH )?

SIADH is a well-known cause of isovolemic hypotonic hyponatremia. Causes of SIADH include central nervous system disorders, pulmonary diseases, and neoplasms. A number of drugs such as vincristine, cyclophosphamide, amitriptyline, desipramine, and carbamazepine are also associated with this syndrome. Case report.