Why is premedication with oral corticosteroids required prior to Taxotere administration?

Why is premedication with oral corticosteroids required prior to Taxotere administration?

For breast and non-small cell lung cancers, premedication consisting of an oral corticosteroid, such as dexamethasone 16 mg per day (e.g. 8 mg BID) for 3 days starting 1 day prior to docetaxel administration, unless contraindicated, can reduce the incidence and severity of fluid retention as well as the severity of …

When do Taxotere side effects start?

Reactions can occur immediately after a patient receives the drug or days later. The most common side effects are blood disorders and fluid retention, which occurred in 64 percent to 96 percent of people in clinical trials.

What drugs are given before chemotherapy?

Premedication before chemotherapy for cancer often consists of drug regimens (usually 2 or more drugs, e.g. dexamethasone, diphenhydramine and omeprazole) given to a patient minutes to hours before the chemotherapy to avert side effects or hypersensitivity reactions (i.e. allergic reactions).

Which is better Taxol or Taxotere?

Taxotere Versus Taxol According to studies, Taxotere showed more benefits to survival than Taxol (paclitaxel), another chemotherapy drug in the same class. Researchers also found docetaxel was more cost effective.

Why is Decadron given with TAXOTERE?

Background: The administration of docetaxel requires the use of dexamethasone for the prevention of hypersensitivity reactions (HSRs) and fluid retention reactions (FRRs). The manufacturer recommends dexamethasone for 3 days starting the day before docetaxel.

How long can you be on Taxotere?

What to Expect During Treatment. Health care providers administer Taxotere through an IV for one hour ever three weeks, according to the drug’s label. Depending on the type of cancer, this can continue for several cycles.

What do you need for first chemo treatment?

9 Must-Have Items to Pack in Your Chemo Bag

• Journal and electronics. Chemotherapy treatment days can be long and emotional.
• Headphones.
• Water bottle.
• Coloring book, crossword, or mind challenges.
• Cozy blanket or scarf.
• Nausea relief.
• Healthy meals or snacks.
• Lipstick.

What are the side effects of Taxotere infusions?

Infusion-related Taxotere side effects (symptoms which may occur during the actual treatment) include: Allergic reactions (rash, flushing, fever, lowered blood pressure). Happens rarely, usually occurs in the first or second infusion. Frequency is reduced by premedication with corticosteroid starting one day before infusion.

When to take corticosteroid prior to Taxotere infusion?

Premedication with a corticosteroid pill starting a day prior to Taxotere infusion for 3 days is given to reduce the severity of fluid retention and allergic reactions. Your doctor will prescribe the exact regimen.

What kind of drug is Taxotere used for?

Taxotere is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. Taxotere is classified as a “plant alkaloid,” a “taxane” and an “antimicrotubule agent.” (For more detail, see “How Taxotere Works” section below). What Taxotere Is Used For:

When to use Taxotere in combination with prednisone?

Taxotere in combination with prednisone is indicated for the treatment of patients with metastatic castration-resistant prostate cancer.